MLB Sports Betting Picks

Expert MLB betting picks, odds and predictions from the DraftKings Network team, updated as the lines move.

Miami Marlins vs. Houston Astros prediction, pick for Wednesday 7/22/26

Miami Marlins vs. Houston Astros prediction, pick for Wednesday 7/22/26

Jul 22, 2026 By Keagan Smith

Chicago Cubs vs. Detroit Tigers prediction, pick for MLB on Wednesday 7/22/26

Chicago Cubs vs. Detroit Tigers prediction, pick for MLB on Wednesday 7/22/26

Jul 22, 2026 By Dan Johnson

Chicago White Sox at Texas Rangers prediction, pick for Wednesday 7/22/26

Chicago White Sox at Texas Rangers prediction, pick for Wednesday 7/22/26

Jul 22, 2026 By Griffin Wong

Minnesota Twins vs. Cleveland Guardians prediction, pick for Wednesday 7/22/26

Minnesota Twins vs. Cleveland Guardians prediction, pick for Wednesday 7/22/26

Jul 22, 2026 By Keagan Smith

Atlanta Braves vs. San Diego Padres prediction, pick for MLB on Wednesday 7/22/26

Atlanta Braves vs. San Diego Padres prediction, pick for MLB on Wednesday 7/22/26

Jul 22, 2026 By Dan Johnson

Boston Red Sox vs. Baltimore Orioles (Game 2) prediction, pick for MLB on Wednesday 7/22/26

Boston Red Sox vs. Baltimore Orioles (Game 2) prediction, pick for MLB on Wednesday 7/22/26

Jul 22, 2026 By Dan Johnson

Philadelphia Phillies vs. Los Angeles Dodgers prediction, pick for MLB on Wednesday 7/22/26

Philadelphia Phillies vs. Los Angeles Dodgers prediction, pick for MLB on Wednesday 7/22/26

Jul 22, 2026 By Sean Barnard

Toronto Blue Jays vs. Tampa Bay Rays prediction, pick for MLB on Wednesday 7/22/26

Toronto Blue Jays vs. Tampa Bay Rays prediction, pick for MLB on Wednesday 7/22/26

Jul 22, 2026 By Dan Johnson

Astros vs. Marlins Betting Splits for Wednesday, July 22

Astros vs. Marlins Betting Splits for Wednesday, July 22

Jul 22, 2026 By DK Network AI

Cubs vs. Tigers Betting Splits for Wednesday, July 22

Cubs vs. Tigers Betting Splits for Wednesday, July 22

Jul 22, 2026 By DK Network AI

Pittsburgh Pirates vs. New York Yankees Game 2 prediction, pick for Wednesday 7/22/26

Pittsburgh Pirates vs. New York Yankees Game 2 prediction, pick for Wednesday 7/22/26

Jul 22, 2026 By Bryan Armetta

Rangers vs. White Sox Betting Splits for Wednesday, July 22

Rangers vs. White Sox Betting Splits for Wednesday, July 22

Jul 22, 2026 By DK Network AI

Braves vs. Padres Betting Splits for Wednesday, July 22

Braves vs. Padres Betting Splits for Wednesday, July 22

Jul 22, 2026 By DK Network AI

Red Sox vs. Orioles Game 2 Betting Splits for Wednesday, July 22

Red Sox vs. Orioles Game 2 Betting Splits for Wednesday, July 22

Jul 22, 2026 By DK Network AI

MLB Picks: Best Strikeout Prop Bets for Wednesday 7/22/26

MLB Picks: Best Strikeout Prop Bets for Wednesday 7/22/26

Jul 22, 2026 By Sam Connon

Blue Jays vs. Rays Betting Splits for Wednesday, July 22

Blue Jays vs. Rays Betting Splits for Wednesday, July 22

Jul 22, 2026 By DK Network AI

Yankees vs. Pirates Game 2 Betting Splits for Wednesday, July 22

Yankees vs. Pirates Game 2 Betting Splits for Wednesday, July 22

Jul 22, 2026 By DK Network AI

Guardians vs. Twins Betting Splits for Wednesday, July 22

Guardians vs. Twins Betting Splits for Wednesday, July 22

Jul 22, 2026 By DK Network AI

St. Louis Cardinals vs. Los Angeles Angels prediction, pick for Wednesday 7/22/26

St. Louis Cardinals vs. Los Angeles Angels prediction, pick for Wednesday 7/22/26

Jul 22, 2026 By Keagan Smith

Seattle Mariners vs. Cincinnati Reds prediction, pick for MLB on Wednesday 7/22/26

Seattle Mariners vs. Cincinnati Reds prediction, pick for MLB on Wednesday 7/22/26

Jul 22, 2026 By Dan Johnson

Phillies vs. Dodgers Betting Splits for Wednesday, July 22

Phillies vs. Dodgers Betting Splits for Wednesday, July 22

Jul 22, 2026 By DK Network AI

Washington Nationals vs. Colorado Rockies prediction, pick for Wednesday 7/22/26

Washington Nationals vs. Colorado Rockies prediction, pick for Wednesday 7/22/26

Jul 22, 2026 By Keagan Smith

Angels vs. Cardinals Betting Splits for Wednesday, July 22

Angels vs. Cardinals Betting Splits for Wednesday, July 22

Jul 22, 2026 By DK Network AI

Diamondbacks vs. Athletics Betting Splits for Wednesday, July 22

Diamondbacks vs. Athletics Betting Splits for Wednesday, July 22

Jul 22, 2026 By DK Network AI