MLB Sports Betting Picks

Expert MLB betting picks, odds and predictions from the DraftKings Network team, updated as the lines move.

Athletics vs. Arizona Diamondbacks prediction, pick for Wednesday 7/22/26

Athletics vs. Arizona Diamondbacks prediction, pick for Wednesday 7/22/26

Jul 22, 2026 By Bryan Armetta

San Francisco Giants at Kansas City Royals prediction, pick for Wednesday 7/22/26

San Francisco Giants at Kansas City Royals prediction, pick for Wednesday 7/22/26

Jul 22, 2026 By Griffin Wong

Mariners vs. Reds Betting Splits for Wednesday, July 22

Mariners vs. Reds Betting Splits for Wednesday, July 22

Jul 22, 2026 By DK Network AI

Rockies vs. Nationals Betting Splits for Wednesday, July 22

Rockies vs. Nationals Betting Splits for Wednesday, July 22

Jul 22, 2026 By DK Network AI

MLB Best Bets: Top player prop bets for Wednesday 7/22/26

MLB Best Bets: Top player prop bets for Wednesday 7/22/26

Jul 22, 2026 By Dan Johnson

Best MLB Parlays Today: Top Picks for Wednesday, July 22

Best MLB Parlays Today: Top Picks for Wednesday, July 22

Jul 22, 2026 By Steve Buchanan

MLB Best Bets: Top home run props for Wednesday 7/22/26

MLB Best Bets: Top home run props for Wednesday 7/22/26

Jul 22, 2026 By Garion Thorne

New York Mets vs. Milwaukee Brewers prediction, pick for Wednesday 7/22/26

New York Mets vs. Milwaukee Brewers prediction, pick for Wednesday 7/22/26

Jul 22, 2026 By Bryan Armetta

Royals vs. Giants Betting Splits for Wednesday, July 22

Royals vs. Giants Betting Splits for Wednesday, July 22

Jul 22, 2026 By DK Network AI

Brewers vs. Mets Betting Splits for Wednesday, July 22

Brewers vs. Mets Betting Splits for Wednesday, July 22

Jul 22, 2026 By DK Network AI

Red Sox vs. Orioles Game 1 Betting Splits for Wednesday, July 22

Red Sox vs. Orioles Game 1 Betting Splits for Wednesday, July 22

Jul 22, 2026 By DK Network AI

Baltimore Orioles vs. Boston Red Sox Game 1 prediction, pick for Wednesday 7/22/26

Baltimore Orioles vs. Boston Red Sox Game 1 prediction, pick for Wednesday 7/22/26

Jul 22, 2026 By Garion Thorne

Yankees vs. Pirates Game 1 Betting Splits for Wednesday, July 22

Yankees vs. Pirates Game 1 Betting Splits for Wednesday, July 22

Jul 22, 2026 By DK Network AI

MLB Best Bets Today: Top NRFI props for Wednesday 7/22/26

MLB Best Bets Today: Top NRFI props for Wednesday 7/22/26

Jul 22, 2026 By Bryan Armetta

Pittsburgh Pirates vs. New York Yankees Game 1 prediction, pick for Wednesday 7/22/26

Pittsburgh Pirates vs. New York Yankees Game 1 prediction, pick for Wednesday 7/22/26

Jul 22, 2026 By Garion Thorne

MLB Rain Delay Watch Today (July 22): Weather Outlook for All 17 MLB Games

MLB Rain Delay Watch Today (July 22): Weather Outlook for All 17 MLB Games

Jul 22, 2026 By DK Network AI

St. Louis Cardinals vs. Los Angeles Angels prediction, pick for Tuesday 7/21/26

St. Louis Cardinals vs. Los Angeles Angels prediction, pick for Tuesday 7/21/26

Jul 21, 2026 By Keagan Smith

Cincinnati Reds at Seattle Mariners prediction, pick for Tuesday 7/21/26

Cincinnati Reds at Seattle Mariners prediction, pick for Tuesday 7/21/26

Jul 21, 2026 By Griffin Wong

Athletics at Arizona Diamondbacks prediction, pick for Tuesday 7/21/26

Athletics at Arizona Diamondbacks prediction, pick for Tuesday 7/21/26

Jul 21, 2026 By Griffin Wong

Washington Nationals vs. Colorado Rockies prediction, pick for Tuesday 7/21/26

Washington Nationals vs. Colorado Rockies prediction, pick for Tuesday 7/21/26

Jul 21, 2026 By Keagan Smith

Miami Marlins vs. Houston Astros prediction, pick for Tuesday 7/21/26

Miami Marlins vs. Houston Astros prediction, pick for Tuesday 7/21/26

Jul 21, 2026 By Keagan Smith

Chicago White Sox vs. Texas Rangers prediction, pick for Tuesday 7/21/26

Chicago White Sox vs. Texas Rangers prediction, pick for Tuesday 7/21/26

Jul 21, 2026 By Bryan Armetta

Detroit Tigers vs. Chicago Cubs prediction, pick for Tuesday 7/21/26

Detroit Tigers vs. Chicago Cubs prediction, pick for Tuesday 7/21/26

Jul 21, 2026 By Keagan Smith

New York Mets at Milwaukee Brewers prediction, pick for Tuesday 7/21/26

New York Mets at Milwaukee Brewers prediction, pick for Tuesday 7/21/26

Jul 21, 2026 By Griffin Wong