MLB Sports Betting Picks

Expert MLB betting picks, odds and predictions from the DraftKings Network team, updated as the lines move.

St. Louis Cardinals at Seattle Mariners prediction, pick for Wednesday 9/10/25

St. Louis Cardinals at Seattle Mariners prediction, pick for Wednesday 9/10/25

Sep 10, 2025 By Zach Thompson

San Diego Padres vs. Cincinnati Reds prediction, pick for Wednesday 9/10/25

San Diego Padres vs. Cincinnati Reds prediction, pick for Wednesday 9/10/25

Sep 10, 2025 By Keagan Smith

Houston Astros at Toronto Blue Jays prediction, pick for Wednesday 9/10/25

Houston Astros at Toronto Blue Jays prediction, pick for Wednesday 9/10/25

Sep 10, 2025 By Garion Thorne

Washington Nationals at Miami Marlins prediction, pick for Wednesday 9/10/25

Washington Nationals at Miami Marlins prediction, pick for Wednesday 9/10/25

Sep 10, 2025 By Zach Thompson

Detroit Tigers at New York Yankees prediction, pick for Wednesday 9/10/25

Detroit Tigers at New York Yankees prediction, pick for Wednesday 9/10/25

Sep 10, 2025 By Griffin Wong

MLB Best Bets: Top MLB predictions and picks for Wednesday 9/10/25

MLB Best Bets: Top MLB predictions and picks for Wednesday 9/10/25

Sep 10, 2025 By Dan Johnson

Kansas City Royals at Cleveland Guardians prediction, pick for Wednesday 9/10/25

Kansas City Royals at Cleveland Guardians prediction, pick for Wednesday 9/10/25

Sep 10, 2025 By Zach Thompson

Pittsburgh Pirates vs. Baltimore Orioles prediction, pick for Wednesday 9/10/25

Pittsburgh Pirates vs. Baltimore Orioles prediction, pick for Wednesday 9/10/25

Sep 10, 2025 By Bryan Armetta

MLB Best Bets: Top Home Run Props for Wednesday 9/10/25

MLB Best Bets: Top Home Run Props for Wednesday 9/10/25

Sep 10, 2025 By Zach Thompson

New York Mets vs. Philadelphia Phillies prediction, pick for Wednesday 9/10/25

New York Mets vs. Philadelphia Phillies prediction, pick for Wednesday 9/10/25

Sep 10, 2025 By Bryan Armetta

Best NRFI Bets Today: No Run First Inning MLB Picks For Wednesday, September 10

Best NRFI Bets Today: No Run First Inning MLB Picks For Wednesday, September 10

Sep 10, 2025 By Bryan Armetta

Boston Red Sox at Athletics prediction, pick for Wednesday 9/10/25

Boston Red Sox at Athletics prediction, pick for Wednesday 9/10/25

Sep 10, 2025 By Garion Thorne

MLB Best Bets Today: DK Network Betting Group Picks for Wednesday 9/10/25

MLB Best Bets Today: DK Network Betting Group Picks for Wednesday 9/10/25

Sep 10, 2025 By DK.Network.Editors

Minnesota Twins at Los Angeles Angels prediction, pick for Wednesday 9/10/25

Minnesota Twins at Los Angeles Angels prediction, pick for Wednesday 9/10/25

Sep 10, 2025 By Charlie Cummings

Arizona Diamondbacks vs. San Francisco Giants prediction, pick for Wednesday 9/10/25

Arizona Diamondbacks vs. San Francisco Giants prediction, pick for Wednesday 9/10/25

Sep 9, 2025 By Brendan O'Sullivan

Milwaukee Brewers at Texas Rangers prediction, pick for Wednesday 9/10/25

Milwaukee Brewers at Texas Rangers prediction, pick for Wednesday 9/10/25

Sep 9, 2025 By Charlie Cummings

St. Louis Cardinals at Seattle Mariners prediction, pick for Tuesday 9/9/25

St. Louis Cardinals at Seattle Mariners prediction, pick for Tuesday 9/9/25

Sep 9, 2025 By Charlie Cummings

Colorado Rockies at Los Angeles Dodgers prediction, pick for Tuesday 9/9/25

Colorado Rockies at Los Angeles Dodgers prediction, pick for Tuesday 9/9/25

Sep 9, 2025 By Griffin Wong

Boston Red Sox vs. Athletics prediction, pick for Tuesday 9/9/25

Boston Red Sox vs. Athletics prediction, pick for Tuesday 9/9/25

Sep 9, 2025 By Brendan O'Sullivan

San Francisco Giants vs. Arizona Diamondbacks prediction, pick for Tuesday 9/9/25

San Francisco Giants vs. Arizona Diamondbacks prediction, pick for Tuesday 9/9/25

Sep 9, 2025 By Keagan Smith

Cincinnati Reds vs. San Diego Padres prediction, pick for Tuesday 9/9/25

Cincinnati Reds vs. San Diego Padres prediction, pick for Tuesday 9/9/25

Sep 9, 2025 By Bryan Armetta

MLB Best Bets Today: Baseball Picks, Predictions for Tuesday 9/9/25

MLB Best Bets Today: Baseball Picks, Predictions for Tuesday 9/9/25

Sep 9, 2025 By Garion Thorne

MLB Best Bets: B/R Betting’s Parlay Picks for Tuesday 9/9/25

MLB Best Bets: B/R Betting’s Parlay Picks for Tuesday 9/9/25

Sep 9, 2025 By DK.Network.Editors

Pittsburgh Pirates at Baltimore Orioles prediction, pick for Tuesday 9/9/25

Pittsburgh Pirates at Baltimore Orioles prediction, pick for Tuesday 9/9/25

Sep 9, 2025 By Garion Thorne