MLB Sports Betting Picks

Expert MLB betting picks, odds and predictions from the DraftKings Network team, updated as the lines move.

Best MLB Picks Today: Top Bets and Player Props for Wednesday 4/22/26

Best MLB Picks Today: Top Bets and Player Props for Wednesday 4/22/26

Apr 22, 2026 By DK.Network.Editors

Cincinnati Reds at Tampa Bay Rays prediction, pick for Wednesday 4/22/26

Cincinnati Reds at Tampa Bay Rays prediction, pick for Wednesday 4/22/26

Apr 22, 2026 By Garion Thorne

MLB Best Bets Today: Top Expert Picks and Predictions for Wednesday 4/22/26

MLB Best Bets Today: Top Expert Picks and Predictions for Wednesday 4/22/26

Apr 22, 2026 By DK.Network.Editors

MLB Best Bets: Top NRFI props for Wednesday 4/22/26

MLB Best Bets: Top NRFI props for Wednesday 4/22/26

Apr 22, 2026 By Bryan Armetta

MLB Best Bets: Top Home Run Props for Wednesday 4/22/26

MLB Best Bets: Top Home Run Props for Wednesday 4/22/26

Apr 22, 2026 By Garion Thorne

St. Louis Cardinals vs. Miami Marlins prediction, pick for MLB on Wednesday 4/22/26

St. Louis Cardinals vs. Miami Marlins prediction, pick for MLB on Wednesday 4/22/26

Apr 21, 2026 By Brendan O'Sullivan

MLB Probable Pitchers Today: Full Starting Pitcher Matchups for April 22, 2026

MLB Probable Pitchers Today: Full Starting Pitcher Matchups for April 22, 2026

Apr 21, 2026 By Steve Buchanan

MLB Best Bets Today: Top Expert Picks and Predictions for April 21, 2026

MLB Best Bets Today: Top Expert Picks and Predictions for April 21, 2026

Apr 21, 2026 By DK.Network.Editors

Best MLB Prop Bets Today (April 21, 2026) – Picks, Props & Odds

Best MLB Prop Bets Today (April 21, 2026) – Picks, Props & Odds

Apr 21, 2026 By Steve Buchanan

New York Yankees at Boston Red Sox prediction, pick for Tuesday 4/21/26

New York Yankees at Boston Red Sox prediction, pick for Tuesday 4/21/26

Apr 21, 2026 By Garion Thorne

MLB Picks: Shota Imanaga Strikeouts Props Philadelphia Phillies vs. Chicago Cubs for Tuesday 4/21/26

MLB Picks: Shota Imanaga Strikeouts Props Philadelphia Phillies vs. Chicago Cubs for Tuesday 4/21/26

Apr 21, 2026 By Sam Connon

Best MLB Picks Today: Top Bets and Player Props for April 21, 2026

Best MLB Picks Today: Top Bets and Player Props for April 21, 2026

Apr 21, 2026 By DK.Network.Editors

Houston Astros at Cleveland Guardians prediction, pick for Tuesday 4/21/26

Houston Astros at Cleveland Guardians prediction, pick for Tuesday 4/21/26

Apr 21, 2026 By Garion Thorne

MLB Best Bets: Top NRFI props for Tuesday 4/21/26

MLB Best Bets: Top NRFI props for Tuesday 4/21/26

Apr 21, 2026 By Bryan Armetta

MLB Best Bets: Top Home Run Props for Tuesday 4/21/26

MLB Best Bets: Top Home Run Props for Tuesday 4/21/26

Apr 21, 2026 By Garion Thorne

MLB Probable Pitchers Today: Full Starting Pitcher Matchups for April 21, 2026

MLB Probable Pitchers Today: Full Starting Pitcher Matchups for April 21, 2026

Apr 20, 2026 By Steve Buchanan

Philadelphia Phillies vs. Chicago Cubs prediction, pick for Monday 4/20/26

Philadelphia Phillies vs. Chicago Cubs prediction, pick for Monday 4/20/26

Apr 20, 2026 By Cooper Albers

Best MLB Parlays Today (April 20, 2026)

Best MLB Parlays Today (April 20, 2026)

Apr 20, 2026 By Steve Buchanan

Los Angeles Angels vs. Toronto Blue Jays prediction, pick for MLB on Monday 4/20/26

Los Angeles Angels vs. Toronto Blue Jays prediction, pick for MLB on Monday 4/20/26

Apr 20, 2026 By Dan Johnson

Kansas City Royals vs. Baltimore Orioles prediction, pick for MLB on Monday 4/20/26

Kansas City Royals vs. Baltimore Orioles prediction, pick for MLB on Monday 4/20/26

Apr 20, 2026 By Dan Johnson

Washington Nationals vs. Atlanta Braves prediction, pick for MLB on Monday 4/20/26

Washington Nationals vs. Atlanta Braves prediction, pick for MLB on Monday 4/20/26

Apr 20, 2026 By Dan Johnson

MLB Picks: Dylan Cease Strikeouts Props Toronto Blue Jays vs. Los Angeles Angels for Monday 4/20/26

MLB Picks: Dylan Cease Strikeouts Props Toronto Blue Jays vs. Los Angeles Angels for Monday 4/20/26

Apr 20, 2026 By Sam Connon

Best MLB Prop Bets Today (April 20, 2026) – Picks, Props & Odds

Best MLB Prop Bets Today (April 20, 2026) – Picks, Props & Odds

Apr 20, 2026 By Steve Buchanan

Cincinnati Reds vs. Tampa Bay Rays prediction, pick for Monday 4/20/26

Cincinnati Reds vs. Tampa Bay Rays prediction, pick for Monday 4/20/26

Apr 20, 2026 By Cooper Albers