Looking for today’s MLB probable pitchers? Here’s the full list of starting pitcher matchups for April 22, 2026, including game times and embedded widgets with odds, strikeout props, and team trends. You can also find the latest odds and player props for today’s games on DraftKings Sportsbook.
Wednesday’s slate features a full schedule of games, highlighted by Jose Soriano carrying dominant early-season form into his matchup with Toronto, Logan Gilbert looking to capitalize on a favorable spot against the Athletics, and Casey Mize bringing improved strikeout numbers into Detroit’s matchup with Milwaukee.
St. Louis Cardinals vs. Miami Marlins Probable Pitchers
- St. Louis Cardinals: Kyle Leahy
- Miami Marlins: Janson Junk
- Time: 12:10 PM ET
Leahy has already allowed four home runs through 19 innings coming into this start. Meanwhile, Junk has really struggled against lefties with a .439 wOBA and 11 of the 13 runs he’s allowed.
Cincinnati Reds vs. Tampa Bay Rays Probable Pitchers
- Cincinnati Reds: Brandon Williamson
- Tampa Bay Rays: Nick Martinez
- Time: 1:10 PM ET
Williamson has issued 10 walks over his last two starts, spanning 9.1 innings. Martinez has a 2.45 ERA through four starts with an xERA of 4.62 and a 4.59 FIP.
Houston Astros vs. Cleveland Guardians Probable Pitchers
- Houston Astros: Peter Lambert
- Cleveland Guardians: Tanner Bibee
- Time: 1:10 PM ET
Lambert’s first start had mixed results, as he allowed four runs on seven hits but also struck out eight in five innings. Bibee bounced back from his worst start of the year against the Braves, as he shut out the Orioles through six innings with five strikeouts.
Baltimore Orioles vs. Kansas City Royals Probable Pitchers
- Baltimore Orioles: Chris Bassitt
- Kansas City Royals: Michael Wacha
- Time: 2:10 PM ET
Bassitt finally kept an offense off the board in his last start, as he shut out the Guardians through five innings. Wacha has yet to allow more than two runs in his first four starts, spanning 27 innings.
Toronto Blue Jays vs. Los Angeles Angels Probable Pitchers
- Toronto Blue Jays: Eric Lauer
- Los Angeles Angels: Jose Soriano
- Time: 3:07 PM ET
Lauer hasn’t been as bad as his 7.13 ERA indicates, but he still owns an xERA of 4.48 and a 5.96 FIP. He’ll take on Soriano, who has allowed just one run through his first five starts.
Athletics vs. Seattle Mariners Probable Pitchers
- Athletics: Aaron Civale
- Seattle Mariners: Logan Gilbert
- Time: 4:10 PM ET
Civale got lit up in his last start against the White Sox, allowing five runs on 11 hits through 4.2 innings. Gilbert is due for some positive regression, as his 4.03 ERA comes with an xERA of 3.03.
Milwaukee Brewers vs. Detroit Tigers Probable Pitchers
- Milwaukee Brewers: Chad Patrick
- Detroit Tigers: Casey Mize
- Time: 6:40 PM ET
Patrick was striking out a hitter per inning last season, but he has only had a 4.2 K/9 through 19 innings this year. Mize has seen an uptick in his strikeouts, going from an 8.4 K/9 last year to his current 9.9 through four starts.
Atlanta Braves vs. Washington Nationals Probable Pitchers
- Atlanta Braves: Martin Perez
- Washington Nationals: Zack Littell
- Time: 6:45 PM ET
Perez shut out the Phillies in his last start, going six clean innings, allowing just four hits and striking out four. Littell continues to give up a ton of home runs, with seven allowed through 19 innings.
New York Yankees vs. Boston Red Sox Probable Pitchers
- New York Yankees: Max Fried
- Boston Red Sox: Ranger Suarez
- Time: 6:45 PM ET
Fried has allowed at least three runs over his last three starts, including five against the Angels last week. Suarez hasn’t allowed a run in his last two starts, spanning 14 innings against the Cardinals and Tigers.
Minnesota Twins vs. New York Mets Probable Pitchers
- Minnesota Twins: TBD
- New York Mets: Clay Holmes
- Time: 7:10 PM ET
While Holmes continues to see his strikeout numbers drop, his ground ball rate continues to rise, currently at 58%.
Philadelphia Phillies vs. Chicago Cubs Probable Pitchers
- Philadelphia Phillies: TBD
- Chicago Cubs: Matthew Boyd
- Time: 7:40 PM ET
Boyd will make his first start since being activated off the IL due to a bicep injury. In his first two starts, he had a 6.75 ERA with a 4.39 xERA and a 16.3 K/9.
Pittsburgh Pirates vs. Los Angeles Angels Probable Pitchers
- Pittsburgh Pirates: Braxton Ashcraft
- Texas Rangers: Jack Leiter
- Time: 8:05 PM ET
Ashcraft has been fantastic thus far, having allowed no more than two runs in his four starts and striking out at least seven in three of them. Leiter has struggled in back-to-back starts, allowing a total of eight runs on 12 hits with seven walks through 9.1 innings.
San Diego Padres vs. Colorado Rockies Probable Pitchers
- San Diego Padres: Walker Buehler
- Colorado Rockies: Tomoyuki Sugano
- Time: 8:40 PM ET
Buehler is generating strikeouts at a rate we haven’t seen since 2021, averaging over a strikeout per inning with a 9.1 K/9. Sugano is a major regression candidate, as his 3.92 ERA comes with a 7.65 xERA and a 5.55 FIP.
Chicago White Sox vs. Arizona Diamondbacks Probable Pitchers
- Chicago White Sox: Anthony Kay
- Arizona Diamondbacks: Eduardo Rodriguez
- Time: 9:40 PM ET
Kay is another regression candidate, as his 2.60 ERA comes with a 6.84 xERA and a 5.53 FIP. Rodriguez turned in his worst start of the season against the Orioles, as he was tagged for four runs on six hits and four walks through five innings.
Los Angeles Dodgers vs. San Francisco Giants Probable Pitchers
- Los Angeles Dodgers: Shohei Ohtani
- San Francisco Giants: Tyler Mahle
- Time: 9:45 PM ET
Ohtani has been almost untouchable on the mound, allowing just one run through 18 innings of work. Mahle has been the complete opposite, as he sports a 7.23 ERA with a 7.09 xERA.
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