Looking for the best MLB picks today? DraftKings Network analysts share their top bets and predictions for Tuesday’s slate on DraftKings Sportsbook.
To see all DraftKings betting analysis, head over to the DraftKings Network sports betting picks page!
Check out the numerous MLB betting markets available on DraftKings Sportsbook!
Garion Thorne: Top Home Run Props
Picks below! Read Garion’s full betting analysis here: MLB Best Bets: Top Home Run Props for Tuesday 4/21/26
Jose Ramirez 1+ Home Run (+391)
Jo Adell 1+ Home Run (+372)
Munetaka Murakami 1+ Home Run (+404)
Bryan Armetta: Top NRFI Bets
Picks below! Read Bryan’s full betting analysis here: MLB Best Bets: Top NRFI props for Tuesday 4/21/26
Brewers vs. Tigers NRFI (-140)
Phillies vs. Cubs NRFI (-125)
Dodgers vs. Giants NRFI (-150)
Garion Thorne: Yankees at Red Sox prediction, pick
Picks below! Read Garion’s full betting analysis here: New York Yankees at Boston Red Sox prediction, pick for Tuesday 4/21/26
Best Bet: Yankees ML (+104)
Strong Lean: Aaron Judge 2+ Total Bases (+105)
Garion Thorne: Astros at Guardians prediction, pick
Picks below! Read Garion’s full betting analysis here: Houston Astros at Cleveland Guardians prediction, pick for Tuesday 4/21/26
