MLB Sports Betting Picks

Expert MLB betting picks, odds and predictions from the DraftKings Network team, updated as the lines move.

San Francisco Giants vs. Chicago White Sox prediction, pick for MLB on Friday 5/2/26

San Francisco Giants vs. Chicago White Sox prediction, pick for MLB on Friday 5/2/26

May 22, 2026 By Dan Johnson

Athletics vs. San Diego Padres prediction, pick for MLB on Friday 5/22/26

Athletics vs. San Diego Padres prediction, pick for MLB on Friday 5/22/26

May 22, 2026 By Dan Johnson

Atlanta Braves vs. Washington Nationals prediction, pick for MLB on Friday 5/22/26

Atlanta Braves vs. Washington Nationals prediction, pick for MLB on Friday 5/22/26

May 22, 2026 By Dan Johnson

Seattle Mariners vs. Kansas City Royals prediction, pick for Friday 5/22/26

Seattle Mariners vs. Kansas City Royals prediction, pick for Friday 5/22/26

May 22, 2026 By Keagan Smith

MLB Best Bets: Top Starting Pitcher Prop Bets for Friday 5/22/26

MLB Best Bets: Top Starting Pitcher Prop Bets for Friday 5/22/26

May 22, 2026 By Zach Thompson

Boston Red Sox vs. Minnesota Twins prediction, pick for MLB on Friday 5/22/26

Boston Red Sox vs. Minnesota Twins prediction, pick for MLB on Friday 5/22/26

May 22, 2026 By Dan Johnson

Colorado Rockies vs. Arizona Diamondbacks prediction, pick for Friday 5/22/26

Colorado Rockies vs. Arizona Diamondbacks prediction, pick for Friday 5/22/26

May 22, 2026 By Bryan Armetta

Most Bet MLB Player Props for Friday 5/22/26

Most Bet MLB Player Props for Friday 5/22/26

May 22, 2026 By Zach Thompson

Philadelphia Phillies vs. Cleveland Guardians prediction, pick for MLB on Friday 5/22/26

Philadelphia Phillies vs. Cleveland Guardians prediction, pick for MLB on Friday 5/22/26

May 22, 2026 By Dan Johnson

Texas Rangers vs. Los Angeles Angels prediction, pick for Friday 5/22/26

Texas Rangers vs. Los Angeles Angels prediction, pick for Friday 5/22/26

May 22, 2026 By Bryan Armetta

Detroit Tigers vs. Baltimore Orioles prediction, pick for Friday 5/22/26

Detroit Tigers vs. Baltimore Orioles prediction, pick for Friday 5/22/26

May 22, 2026 By Cooper Albers

MLB Best Bets: Top player prop bets for Friday 5/22/26

MLB Best Bets: Top player prop bets for Friday 5/22/26

May 22, 2026 By Dan Johnson

New York Mets vs. Miami Marlins prediction, pick for Friday 5/22/26

New York Mets vs. Miami Marlins prediction, pick for Friday 5/22/26

May 22, 2026 By Bryan Armetta

Los Angeles Dodgers at Milwaukee Brewers prediction, pick for Friday 5/22/26

Los Angeles Dodgers at Milwaukee Brewers prediction, pick for Friday 5/22/26

May 22, 2026 By Griffin Wong

MLB Best Bets Today: Top Expert Betting Picks for Friday 5/22/26

MLB Best Bets Today: Top Expert Betting Picks for Friday 5/22/26

May 22, 2026 By DK.Network.Editors

Best MLB Prop Bets Today (May 22, 2026) – Picks, Props & Odds

Best MLB Prop Bets Today (May 22, 2026) – Picks, Props & Odds

May 22, 2026 By Steve Buchanan

Tampa Bay Rays at New York Yankees prediction, pick for Friday 5/22/26

Tampa Bay Rays at New York Yankees prediction, pick for Friday 5/22/26

May 22, 2026 By Griffin Wong

Pittsburgh Pirates at Toronto Blue Jays prediction, pick for Friday 5/22/26

Pittsburgh Pirates at Toronto Blue Jays prediction, pick for Friday 5/22/26

May 22, 2026 By Garion Thorne

MLB Picks Today: Top Home Run Prop Bets for Friday 5/22/26

MLB Picks Today: Top Home Run Prop Bets for Friday 5/22/26

May 22, 2026 By Zach Thompson

MLB Best Bets: Top NRFI props for Friday 5/22/26

MLB Best Bets: Top NRFI props for Friday 5/22/26

May 22, 2026 By Bryan Armetta

MLB Probable Pitchers Today: Full Starting Pitcher Matchups for May 22, 2026

MLB Probable Pitchers Today: Full Starting Pitcher Matchups for May 22, 2026

May 21, 2026 By Steve Buchanan

Houston Astros vs. Chicago Cubs prediction, pick for MLB on Friday 5/22/26

Houston Astros vs. Chicago Cubs prediction, pick for MLB on Friday 5/22/26

May 21, 2026 By Brendan O'Sullivan

Colorado Rockies vs. Arizona Diamondbacks prediction, pick for Thursday 5/21/26

Colorado Rockies vs. Arizona Diamondbacks prediction, pick for Thursday 5/21/26

May 21, 2026 By Bryan Armetta

MLB Best Bets: Top player prop bets for Thursday 5/21/26

MLB Best Bets: Top player prop bets for Thursday 5/21/26

May 21, 2026 By Dan Johnson