Sunday afternoon’s loaded NFL Week 10 slate features an AFC East showdown between the Buffalo Bills and the New York Jets at MetLife Stadium, with kickoff set for 1 p.m. ET.
The Bills (7–1, 1st AFC East) have won four straight, capped by a 23–6 road win over the Minnesota Vikings on Monday Night Football. The Jets (2–7, 3rd AFC East) have lost four straight, most recently falling on the road against the Kansas City Chiefs, 35–12.
Buffalo is a 7.5-point road favorite with -395 moneyline odds on DraftKings Sportsbook. New York is a +310 underdog, with the game total set at O/U 50.5 points.
Let’s dive into the top player prop bets for Sunday’s clash between the Bills and the Jets.
Bills vs. Jets NFL Player Prop Bets on DraftKings Sportsbook
James Cook III | 20+ Rush Attempts (-112)
James Cook III had to roll up his sleeves in Week 9, muscling a season-high 31 carries for 107 yards and a touchdown in the Bills’ MNF win over the Vikings. The star running back is tied for third in the NFL with 169 carries and has logged 20+ rush attempts in six of his eight games in 2026 — including four straight heading into Sunday afternoon.
Cook, 27, should stay busy in Week 10, as Buffalo is favored by more than a touchdown against the turbulent Jets. Playing from behind for much of the season, New York has allowed the NFL’s fifth-most rushing yards (993) and the second-most carries (238) to opposing RBs.
Garrett Wilson | 70+ Receiving Yards (+133)
Garrett Wilson is expected to return to the gridiron after missing last week’s loss to the Chiefs due to a concussion. If the star receiver suits up, he’s well-positioned to build on one of his best games in a minute.
Facing the Las Vegas Raiders in Week 8, Wilson nabbed six catches on 12 targets for 83 yards — more than he had in Weeks 6 (44) and 7 (26) combined. The 26-year-old wideout has now topped 70 receiving yards in four of his eight games this season.
The Jets should keep the ball in the air as heavy underdogs against the Bills, who lead the NFL in scoring (32 points per game). Negative game script should favor New York’s top receiver, with Buffalo allowing the league’s fourth-most opponent passing yards per contest (238.8).
