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Ole Miss Rebels vs. Oklahoma Sooners prediction, pick for College Football on Sunday 11/15/26

Ole Miss Rebels vs. Oklahoma Sooners prediction, pick for College Football on Sunday 11/15/26

Published:

By: Caleb Wilfinger

The college football season approaches the home stretch this week with a number of notable matchups across the Power 4 and Group of 6 ranks. The SEC plays host to an intriguing matchup between teams trending in different directions, as we’ll see the Ole Miss Rebels take on the Oklahoma Sooners in Norman.

Ole Miss enters this game off a horrific blowout loss at the hands of Georgia, while Oklahoma pulled off an upset on the road in a dominant victory over Florida. Below is my preview, prediction, and pick for Sunday’s college football game between Ole Miss and Oklahoma.

Oklahoma is a 2.5-point favorite for this matchup with the total listed at 49.5 at DraftKings Sportsbook. Let’s dig into the odds and my best bet on Sunday’s matchup, and don’t miss our complete coverage of all of the Week 11 college football action at DraftKings Network.

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Ole Miss vs. Oklahoma Prediction

These are a pair of teams that appear to be heading in opposite directions heading into this week. Ole Miss has dropped two of its last three games, including a 42-7 drubbing at the hands of Georgia a week ago. It was one of the most hyped games on the schedule for the Rebels and it was the kind of deflating result that can really take the wind out of the sails of a team that was hoping to qualify for the postseason. I don’t see Pete Golding’s team bouncing back from that kind of loss, especially since it effectively knocked the Rebels out of the College Football Playoff discussion.

After entering the season with high expectations, it’s turned into a disappointing campaign for Trinidad Chambliss and company. With that in mind, it’s reasonable to wonder if the Rebels will show up for this week’s game given the injuries they’ve sustained and the fact that the postseason is out of reach. The same can’t be said for an Oklahoma team that suddenly feels rejuvenated following last week’s victory over the Florida Gators in the Swamp.

Despite all of their struggles this season, the ceiling is relatively high for this Oklahoma team. After all, the Sooners did knock off Texas and held a lead over Kentucky for the majority of that game. A change at offensive coordinator seemed to make a noticeable difference in the run game, as the Sooners ran all over Florida a week ago — including a game-clinching touchdown drive that took over 13 minutes off the clock. If they’re able to run the ball effectively once again on Sunday, that will take a lot of the pressure off Mateer and put the quarterback in position to succeed on crucial downs.

Defensively, Oklahoma is getting healthier and a matchup against Chambliss shouldn’t be too daunting for one of the best units in the sport. It’s also worth mentioning that Chambliss has struggled against top-tier defenses this season (Georgia and Texas), and this is simply not the same offense as last year. Now, with running back Kewan Lacy out for this game, I fully expect Oklahoma to bottle up the Ole Miss ground attack and make Chambliss beat them on third and long.

Ole Miss vs Oklahoma Best Bet

Earlier in the season, I would have stayed away from this matchup. However, I liked what I saw from Oklahoma a week ago and Ole Miss could be going through the motions a bit following last week’s disappointing result. Let’s take the Sooners on the money line.

Best Bet: Oklahoma ML (-135)

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