DraftKings Pick6 Picks: Best NFL Plays for Week 10

The 2026-27 NFL season is halfway through. One of DraftKings’ more unique features this season is Pick6 Fantasy Football!

Here are my top Pick6 plays for the Week 10 Sunday slate.

DraftKings Pick6 Picks: Best NFL Plays for Sunday in Week 10

Kyren Williams More Than 0.5 Rushing + Receiving Touchdowns

Kyren Williams is going to be taking on a much bigger role in the Rams’ offense moving forward. Puka Nacua is out long-term, and Davante Adams remains out. The Rams’ superstar wide receiver duo is not going to be on the field together anytime soon. That means Los Angeles will need to lean more heavily on its running game. Kyren Williams is more than up to the task. He has always been considered the supporting player in this offense rather than the engine, but he has been one of the best running backs in the league over the last several seasons.

Since the start of the 2023 season, only Derrick Henry and Jahmyr Gibbs have scored more touchdowns than Kyren Williams. Williams is also one of seven players with over 4,000 rushing yards over that same stretch. He stands alongside the likes of Henry, Gibbs, Bijan Robinson, James Cook, Jonathan Taylor and Saquon Barkley in terms of his production, but doesn’t get the same respect. That might change if he can take the spotlight for the surging Rams. Williams should get plenty of touches in this game and find paydirt against a Cardinals team that could really struggle to keep possession of the football.

Tyler Warren More Than 45.5 Receiving Yards

Tyler Warren is another player who should see an increase in usage for the rest of this regular season. Keenan Allen and Josh Downs, the Colts’ top two receivers this season, both got traded away. Their wide receiver room looks much more like a CFL group than an NFL group. That should lead to an incredibly high target share for Tyler Warren.

This is an excellent matchup for Tyler Warren as well. The Dolphins rank 31st in the NFL in defensive EPA/dropback and 32nd in defensive dropback success rate. They are giving up over 64 yards per game to opposing tight ends this season as well. This is going to be a rough rest of the season for the Colts, but this is a spot for them to let some of their frustrations out. Not only do the Dolphins have one of the worst defenses in the league, but they will be starting Kyle McCord at quarterback. The Colts’ defense should be fine in this game and get the ball back for their offense frequently. This is a great chance for Tyler Warren to have a big game in the midst of a tough season.

Bryce Young More Than 244.5 Passing Yards

Bryce Young is quietly having a nice season despite the Panthers’ poor record. He ranks eighth in the league in passing yards, seventh in passing touchdowns and 10th in QBR. Young should be in for a good game in New Orleans. The Saints rank 22nd in the NFL in defensive EPA/dropback and 26th in defensive dropback success rate. The indoor conditions in the dome also eliminate any sort of weather variable that could hamper Young.

Young has thrown for at least 276 yards in six of eight games played this season. Only a road trip to Lambeau Field and a nightmare performance against a great Tampa Bay defense have kept Young under 276 passing yards this season. This play only requires him to throw for 245 yards against the Saints. This is a huge game for the Panthers, and Young should step up and deliver a good performance in New Orleans.

What is DraftKings Pick6?

Pick6 is a peer-to-peer fantasy variant where you build a lineup (your “Pick Set”) of 2+ players and select whether you believe each will outperform their listed stat projection. Enter your Pick Set in Pick6 contests to compete against other users. Get enough picks correct and win a share of cash prizes.

How to Play

Create a Pick Set

Create a Pick Set by choosing 2+ players from the same sport and Pick Group (a set of picks available from a group of set competitions). For each player, simply select if you think they’ll have more or less than their listed stat projection. In each Pick Set, you can not pick the same player twice, and you must pick players from at least two different teams.

Enter an Amount

Once you finalize your Pick Set, choose your entry fee amount. Your entries will be automatically distributed into available contests, subject to your confirmation.

Sweat Your Picks

When the games go live, use the My Picks tab to follow your picks in real time to track how your players are performing against their projections and how they stack up against other users.

Compete for Prizes

Make enough correct picks and win a share of the contests’ guaranteed prizes. Any prizes won will be credited to your DraftKings account after contests are finalized.

Play at DraftKings Pick6 or by downloading the DraftKings Pick6 app on Apple or Google!