DraftKings NFL Millionaire Picks: Best DFS Plays for Week 10

Kicking off Sunday’s Week 10 NFL slate, the New England Patriots will face off with the Detroit Lions in a matchup in Germany. The Chicago Bears, Philadelphia Eagles, Denver Broncos, and Tampa Bay Buccaneers are all on bye. There are seven games in the 1 p.m. ET window and three games in the afternoon slate before the Pittsburgh Steelers face off with the Cincinnati Bengals to close out the day on Sunday Night Football.

You can join the action with DraftKings Sportsbook and DFS contests. To maximize your DFS lineups, here are a few players poised to outperform their salaries and give you an edge across Sunday’s slate. Here’s my top DFS lineup and the logic behind each selection.

Set your DraftKings fantasy football lineups here: NFL $2.5M Fantasy Football Millionaire [$1M to 1st]

DraftKings NFL Millionaire Picks: Best DFS Plays for Week 10

Quarterback

Trevor Lawrence ($6,600)

Trevor Lawrence has been a major reason for Jacksonville’s strong season. The former No. 1 overall pick has completed 65.2% of his passes for 1,932 yards, 18 touchdowns, and four interceptions. Lawrence is averaging 19.8 fantasy points per game on DraftKings scoring, which ranks 13th among all quarterbacks. This week’s matchup against the 1-7 Titans gives him a chance to build on that production. Tennessee’s vulnerable passing defense makes Lawrence an appealing DFS play. They rank 23rd in opponent points allowed, 31st in total yards conceded, 31st in passing yards allowed, and T-29th in yards per pass attempt. Jacksonville has the receiving talent to create explosive plays, and pairing Lawrence with Parker Washington gives this lineup a direct connection to those scoring opportunities. A comfortable Jaguars lead could limit passing volume later in the game, but Lawrence can produce before that becomes a concern. Expect him to lead Jacksonville’s offense and provide a strong foundation under center.

Other Considerations: Josh Allen ($7,500), Brock Purdy ($7,000), Tyler Shough ($5,600), Michael Penix Jr. ($4,900)

Running Back

Christian McCaffrey ($8,500)

Christian McCaffrey remains one of the most versatile offensive weapons in football. Through eight games, the 49ers star has rushed for 457 yards and nine touchdowns, adding 36 receptions for 270 yards and another score. That receiving involvement is especially valuable under DraftKings’ full-PPR scoring. McCaffrey can contribute even when rushing lanes are limited, while his role near the goal line provides significant touchdown upside. Dallas presents an appealing matchup for San Francisco’s offense. The Cowboys enter the week ranked T-25th in points allowed, 30th in total yards conceded, 31st in rushing yards allowed, T-26th in rushing touchdowns conceded, and T-32nd in yards per carry. Expect the 49ers to keep McCaffrey involved as both a runner and receiver, giving him multiple paths to justify his premium salary.

Breece Hall ($5,900)

Breece Hall returned from an extended injury absence in Week 9 and immediately handled a meaningful workload. He finished with 15 carries for 61 yards plus three receptions for 26 yards against Kansas City. Through four appearances, Hall has totaled 224 rushing yards and 128 receiving yards. The production has been uneven, but his involvement in the passing game gives him another way to contribute in this week’s matchup against Buffalo. The Bills’ run defense presents a challenge, and a negative game script could limit Hall’s rushing opportunities. Still, his receiving role helps offset that concern. At $5,900, I am backing Hall to find a way to leave his mark on the game.

Other Considerations: Javonte Williams($7,500), Kyren Williams ($7,100), Woody Marks ($5,700), Jordan Mason ($5,300)

Wide Receivers

Parker Washington ($6,200)

Parker Washington has taken a step forward alongside Lawrence this season. The Penn State product has caught 29 passes on 55 targets for 493 yards and five touchdowns, establishing himself as the leading presence in Jacksonville’s passing attack. Washington gives this lineup a stack with Lawrence against a vulnerable Tennessee secondary. If the Jaguars generate multiple passing touchdowns, this duo provides a chance to benefit from both ends of the same scoring plays. The primary concern is Jacksonville building a lead and leaning on its rushing attack. However, Washington’s downfield opportunities and touchdown production make him an appealing tournament selection. Expect him to have chances to create explosive plays and outperform his $6,200 salary.

Deebo Samuel Sr. ($5,500)

Deebo Samuel Sr. has returned to San Francisco and remains a versatile option in the offense. Through five appearances, he has recorded 16 receptions for 206 yards and three touchdowns, along with 78 rushing yards. Samuel is returning from a hamstring injury, so his workload is uncertain. However, he finished the practice week without a game designation, and the matchup against Dallas offers an opportunity to make an immediate impact. San Francisco can involve Samuel through short passes, designed touches, and opportunities after the catch. His role overlaps with McCaffrey’s in some situations, but both can contribute to a productive offensive performance. At $5,500, Samuel offers an affordable way to gain additional exposure to this matchup.

Devaughn Vele ($4,900)

Devaughn Vele has become a useful part of the Saints’ passing attack. Through eight games, he has caught 35 passes on 50 targets for 365 yards and three touchdowns. Those totals translate to 11.2 DraftKings points per game, giving him a reasonable production base at a $4,900 salary. New Orleans has won two of its last three games and now faces Carolina in a divisional matchup. Vele does not need to dominate the target share to provide value. A handful of receptions, solid yardage, and a touchdown would put him in position to outperform this price. Expect him to remain involved as the Saints look to build on their recent momentum.

Other Considerations: CeeDee Lamb ($8,800), Chris Olave ($7,000), George Pickens ($6,300), Khalil Shakir ($5,300)

Tight End

Harold Fannin Jr. ($4,700)

Harold Fannin Jr. has developed into an important weapon for Cleveland’s passing attack. Through nine games, he has caught 37 passes on 53 targets for 453 yards and four touchdowns. His upside was on full display in Week 8, as he finished with 10 catches on 12 targets for 154 yards against Pittsburgh. That type of volume is particularly valuable on DraftKings, where receptions and the 100-yard receiving bonus can elevate a tight end’s production. Fannin will reunite with Deshaun Watson this week after the QB missed Cleveland’s previous game.

The Texans also have significant defensive injury concerns, with Danielle Hunter being ruled out and Will Anderson Jr. listed as questionable. Expect Cleveland to keep Fannin involved, giving him a chance to deliver another productive outing at a manageable salary.

Other Considerations: George Kittle ($6,500), Travis Kelce ($4,700), Tyler Higbee ($4,200)

Flex

Tutu Atwell ($3,700)

Injuries have created opportunities throughout the Rams’ passing attack. Puka Nacua was placed on injured reserve this week with knee and toe injuries, joining Davante Adams on the sideline. Tutu Atwell has caught just seven passes for 99 yards this season, so this selection is based on an anticipated increase in opportunity rather than established production. Atwell’s speed gives him a chance to produce on limited touches. Sean McVay can create opportunities through motion, play-action, and designed looks that put him in space. This is one of the lineup’s more volatile selections, but the $3,700 salary helps accommodate premium players elsewhere. I am backing Atwell to capitalize on the expanded opportunity against Arizona.

Defense & Special Teams

Los Angeles Rams ($3,800)

The Rams have an appealing matchup against an Arizona offense undergoing another quarterback change. The Cardinals traded Jacoby Brissett to Baltimore before losing Gardner Minshew to a season-ending elbow injury, leaving third-round rookie Carson Beck to make his first career NFL start. Beck showed encouraging signs during the preseason, but facing a defensive front featuring Myles Garrett and Aaron Donald is a nightmare debut matchup. Los Angeles has the personnel to pressure him and create opportunities for sacks and turnovers. A rookie quarterback does not automatically guarantee defensive fantasy production, but the circumstances favor the Rams. Arizona must adjust to another starter while attempting to protect him against an intimidating pass rush. At $3,800, Los Angeles offers an appealing combination of pressure potential and matchup upside. Expect the Rams to challenge Beck early and create opportunities to produce on defense.

Other Considerations: Jaguars ($4,000), Seahawks ($3,300), Saints ($2,700)