NFL Week 10 Pick’Em Picks and Predictions

There are so many different ways to get in on the action at DraftKings Sportsbook this NFL season. One of the best ways is by joining a weekly NFL Pick’Em pool. These pools require you to pick every game on the NFL slate against the spread.

You can enter the DraftKings NFL Pick’Em Pools here.

NFL Week 10 Pick’Em Pool Picks, Predictions and Strategy

Here are my five favorite selections to use this week in NFL against-the-spread pools.

NFL Week 10 Picks

Panthers +1.5 at Saints — The Saints are really struggling this season. They barely squeaked out a one-point home win last week against a Shedeur Sanders-led Browns team. The Saints are now 1-3 SU and 0-4 ATS at home this season. That one win came against a backup quarterback on a failed two-point conversion in overtime. The Panthers should be able to come to New Orleans and get a win.

Carolina has been the better team on both sides of the ball this season. They rank 13th in the NFL in offensive EPA/play and 23rd in defensive EPA/play. Meanwhile, the Saints rank 22nd in offensive EPA/play and 26th in defensive EPA/play. The Panthers’ offense is clearly the best unit between the two teams. The Saints keep putting themselves in early holes. They are 4-13 ATS in the first half with Tyler Shough at quarterback. The Panthers should jump on them early and ride their way to a win. If it comes down to another two-point conversion in overtime, the Panthers would still cover that 1.5-point spread.

Jets +8.5 vs. Bills — The Jets are massively underperforming their talent, due largely to the horrific coaching by Aaron Glenn and his staff. New York has a great group of skill position players, a solid offensive line and Geno Smith is playing really well. However, the points on the board aren’t translating to the offensive potential. The defense isn’t entirely well-rounded, but there is some promising young talent like David Bailey making impact plays for the Jets. This team is much better on paper than it has been on the field, which is an indictment of the coaching staff.

That being said, the Jets should be able to keep it within one score against the Bills at home. MetLife Stadium is a place that Josh Allen has struggled over the years. The Jets are 2-2 SU and 3-1 ATS in their last four home games against the Bills. This is also a tough spot for Buffalo. The Bills are on short rest after playing on the road against the NFL’s best defense in Minnesota last week. Now, they need to get up again after that big win to face a Jets team that they are much better than. The Jets have not been good this season, but they have not lost a home game by more than five points. They should put up a decent fight and cover this large spread.

Titans +10.5 vs. Jaguars — There are signs of optimism around the Titans over the past few weeks. Over their past three games, they beat the Colts, suffered a three-point loss to the Browns and went to overtime with the Bengals. Now, they are coming off a bye week and should be very prepared for this big divisional matchup at home. Since Week 6, the Titans rank 17th in offensive EPA/play and 14th in offensive success rate, a big improvement over where they were at the beginning of the season. Cam Ward seems to be growing in confidence as an NFL quarterback, and he should play well after having two weeks to prepare for this game.

The Jaguars have played great this season, but they have not faced a lot of real tests. They rolled the past two weeks against the Joe Fagnano-led Ravens and the Colts, who had basically punted on their season. The Jaguars’ three results prior to those blowout wins were a five-point win over the Bengals, a two-point win over the Eagles and a loss to the Texans. Despite their results the past two weeks, this team is not a world-beater. The Titans should make the most of their rest advantage and cover this big spread at home.

Cowboys +4.5 vs. 49ers — The Cowboys have a chance to go on the big run needed to get back into NFC East contention. They have won two of their past three games, and after this week, they have home games against the Titans and Eagles. If the Cowboys can pull off the upset over the 49ers, they have a real chance to be looking at 7-5 in a couple of weeks. That would put them in a great position to compete for the NFC East crown over the final third of the season.

It will be no easy task to take down the 49ers here. San Francisco has the best offense in the NFL by EPA/play. The Cowboys are not far behind, however, ranking sixth in offensive EPA/play. This game has all of the makings of a shootout between two great offenses in prime conditions at AT&T Stadium. The Cowboys’ offense should be able to produce at home, where they are almost always excellent. The Cowboys have inexplicably blown games as favorites this season. However, they are 7-2 ATS as underdogs and 3-0 ATS as home underdogs since the start of last season.

The 49ers have played five of their eight games this season at home. They are a perfect 5-0 SU at Levi’s Stadium, and 1-0 on a neutral site. They have only played two true road games all season, and in those games, they lost to the Falcons and beat the Seahawks by three points. There is real evidence that this 49ers team might not be as dangerous heading to the Central Time Zone, while the Cowboys have been much better at home during the Dak Prescott era. The Cowboys should score enough to cover this spread, and could pull off the upset.

Steelers +3.5 at Bengals — In these AFC North matchups, it’s always tempting to just blindly take the underdog. However, in this matchup, there is plenty of evidence to support taking the dog. The Steelers have a massive rest advantage in this game. They are coming off the bye week and have had two weeks to prepare for this matchup. Meanwhile, the Bengals played in Madrid last week. So, while they have been flying overseas and dealing with time zone changes, in addition to playing another football game, the Steelers have been at home preparing for this matchup.

The Steelers were also red hot prior to the bye week. They are riding a four-game winning streak and should have been feeling great about themselves during the bye. The Steelers have been running the ball brilliantly with Jaylen Warren, which has subsequently opened up the passing game for Aaron Rodgers. Since Week 5, the Steelers lead the NFL in offensive EPA/rush. Over that same period, the Steelers rank third in the NFL in defensive EPA/rush. They are running the ball efficiently and stopping the run, allowing them to completely control games.

Pittsburgh won the first matchup between these teams this season 30-27 at home. This week’s result could be as simple as flipping that field goal difference towards the home team. The Bengals are playing great football as of late and could easily win this game at home, while the Steelers still cover the 3.5-point spread. Aaron Rodgers is 2-0 SU and ATS in his career against Joe Burrow. The Steelers are 37-17-1 ATS against the Bengals since 2000. Both long-term and recent history tell us that the Steelers should cover this game.