Week 2 of the 2026 NFL season kicks off Thursday in Buffalo, New York as the Bills and Lions face off. This matchup is set to be a barn burner, with plenty of points put up on the board. Here are my Bills-Lions anytime TD scorer picks for Week 2.
Buffalo Bills vs. Detroit Lions Anytime TD Scorer Picks, Best Bets
| Player | Odds | Team | Position |
| Josh Allen | -130 | Bills | QB |
| Amon-Ra St. Brown | +100 | Lions | WR |
| Joshua Palmer | +550 | Bills | WR |
| Sione Vaki | +950 | Lions | RB |
Josh Allen (-130)
Fresh off two rushing touchdowns in the 2026 season opener, it feels like there’s actually plenty of value on -130 for Josh Allen to find the end zone himself again on Thursday night. The former MVP already has the most rushing touchdowns all-time by a quarterback, and he appears primed to build on his lead this year. Allen has never scored fewer than six rushing TDs in a year, and he’s racked up at least 12 in three straight campaigns. As I said earlier, -130 actually feels like a strong value play given that context.
Amon-Ra St. Brown (+100)
Speaking of guys who just find the end zone, Amon-Ra St. Brown is a scoring machine. Detroit’s star wideout has scored double-digit times in three straight years, and he added two to his 2026 tally in the first game of the year. Call it the product of an elite Lions system if you want, but St. Brown drastically outdoes the expected TD production of a 6’0, slender receiver. He’ll look to build on his strong start to the year against a Bills defense that surrendered 31 points to CJ Stroud and the Texans. Even money also feels like solid value on a guy who scores as much as St. Brown does.
Bills vs. Lions Anytime TD Long Shots
Joshua Palmer (+550)
When you have a quarterback as talented as Josh Allen, anyone who steps on the field as his potential target has a path to scoring. That’s exactly what happened with Joshua Palmer in Week 1. The versatile receiver saw two targets against the Texans and hauled in one of them for the game-winning touchdown. That moment should translate to more opportunities for Palmer on Thursday night.
Sione Vaki (+950)
When you have so many players in a given game capable of finding the end zone, it can be hard to find true long shot value. However, all the Lions do is put points on the board, and Sione Vaki gets on the field. Vaki played 29% of offensive snaps in Week 1, receiving three touches. Jahmyr Gibbs carrying the ball 29 times isn’t sustainable, so it’s fair to expect Vaki to get a few more opportunities moving forward. There’s a reason he’s +950 to find the end zone, but Vaki has a path to doing so.
Bills vs. Lions Anytime Touchdown Scorer Odds
Find live anytime TD odds for Bills vs. Lions here!
Stay tuned for more Week 2 anytime TD scorer picks later this week!
