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Best Amon-Ra St. Brown Prop Bet for Lions vs. Bills on Thursday 9/17/26

Best Amon-Ra St. Brown Prop Bet for Lions vs. Bills on Thursday 9/17/26

NFL Sports Betting Picks DraftKings Sportsbook Insights

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By: Alex Hunter

The Lions are visiting the Bills for Week 2 on Thursday Night Football. Buffalo is a 5.5-point favorite on DraftKings Sportsbook, with the game total set at 54.5 points.

Let’s dive into the top Amon-Ra St. Brown prop bet for Thursday’s matchup.

Best Amon-Ra St. Brown Prop Bet on DraftKings Sportsbook

Amon-Ra St. Brown 10+ First-Quarter Receiving Yards (-135)

Amon-Ra St. Brown got off to a quick start in last Sunday’s season opener against the Saints, catching 3 of 4 targets for 18 yards in the first quarter. This has been the norm for St. Brown, as he led the NFL with 437 first-quarter receiving yards in 2025.

Since the start of 2025, St. Brown is averaging 25.3 first-quarter receiving yards per game and he has posted 10+ first-quarter receiving yards in 13-of-18 games. In that span, he owns a 28.8% target share — which swells to 33.6% in the first period.

RELATED Buffalo Bills vs. Detroit Lions prediction, pick for NFL Week 2 on Thursday 9/17/26

Following their thrilling overtime victory over the Saints in Week 1, the Lions are looking at another shootout against the Bills. This matchup’s 54.5-point total on DraftKings Sportsbook is the highest in the NFL this season. St. Brown has typically flourished in high-scoring matchups, recording at least 33 receiving yards in four of his last six games with a total of 50 or more points.

Buffalo ranks first in pace since the start of last season, so Detroit will likely have at least two drives in the first quarter. The Bills have a strong secondary, but they allowed the fifth-most receiving yards to slot receivers in Week 1 (98). This bodes very well for St. Brown, as 50.9% of his routes have come from the slot since the start of 2025.

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Alex Hunter
Alex Hunter is an avid DFS player and sports handicapper, who has been a proud member of the DraftKings Network team since 2020. He is a data-driven analyst, who earned his bachelor’s degree in communications at Worcester State University and has been in the sports content business for nearly a decade, covering the NBA, NFL and PGA TOUR. Alex is a diehard Boston Celtics fan, who loves to be on the golf course when he isn’t grinding lineups or producing content. For all of Alex’s work or if you need any lineup advice, be sure to follow him @Hunta512 on X.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user (my username is Hunta512) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.