New Orleans Saints vs. San Francisco 49ers prediction, pick for NFL Week 2 on Sunday 9/14/25
The Superdome opens its doors to a bruised heavyweight and a hungry underdog, and the market is still trying to sort out which story wins. San Francisco sits -3 with a total of 40.5, yet the pre-game eye test says this one should be 50%–50%. Injury context bends this matchup toward attrition football. QB Brock […]
September 13, 2025