The Los Angeles Rams and San Francisco 49ers meet Thursday night in Melbourne, giving NFL fans an international divisional matchup to open Week 1. We’ve built the best Rams vs. 49ers parlays at DraftKings Sportsbook, including touchdown scorer, first-drive and defensive prop options.
Matthew Stafford, Puka Nacua and Kyren Williams lead the Rams, while Brock Purdy, Christian McCaffrey and San Francisco’s offense offer several ways to build a same-game parlay. Check out the featured Rams vs. 49ers bets below before kickoff.
Anytime in Primetime: Touchdown Parlay
Thursday night’s matchup between the Rams and 49ers features three players with paths to the end zone. This touchdown parlay backs Puka Nacua and Blake Corum for Los Angeles, along with Christian McCaffrey for San Francisco.
- Puka Nacua anytime touchdown scorer
- Christian McCaffrey anytime touchdown scorer
- Blake Corum anytime touchdown scorer
Endzone Hunt: Anytime Touchdown Parlay
This touchdown parlay features four of the NFL’s most productive scorers from last season. Christian McCaffrey, Davante Adams, Kyren Williams and Javonte Williams all found the end zone at least 13 times in 2025.
- Christian McCaffrey anytime touchdown scorer
- Davante Adams anytime touchdown scorer
- Kyren Williams anytime touchdown scorer
- Javonte Williams anytime touchdown scorer
Ram It Up: Rams First-Drive Parlay
Los Angeles’ first possession in Melbourne gives the Rams an early opportunity to set the tone against San Francisco.
- Matthew Stafford 30+ passing yards on the first Rams drive
- Puka Nacua 10+ receiving yards on the first Rams drive
- Kyren Williams 5+ rushing yards on the first Rams drive
Gold Rush: 49ers First-Drive Parlay
San Francisco’s opening possession is the focus of this first-drive parlay against the Rams. It backs Brock Purdy to move the ball early, with Mike Evans and Christian McCaffrey contributing to the 49ers’ first series.
- Brock Purdy 20+ passing yards on the first 49ers drive
- Mike Evans 5+ receiving yards on the first 49ers drive
- Christian McCaffrey 1+ reception on the first 49ers drive
Game Wrecker: Myles Garrett Sacks Special
Myles Garrett set the regular-season sack record last year, and this special looks for him to make a major impact against the 49ers in his Rams debut. Back Garrett to record multiple sacks in Thursday night’s matchup.
- Myles Garrett 2+ sacks
Rams vs. 49ers Parlay FAQ
What are the best Rams vs. 49ers parlays for Thursday night?
Our featured Rams vs. 49ers parlays include touchdown scorer bets, first-drive player props and a Myles Garrett sack special. The cards above feature Matthew Stafford, Puka Nacua, Kyren Williams, Brock Purdy, Christian McCaffrey and other key players from Thursday’s matchup in Melbourne.
Which Rams players are featured in these parlays?
The Rams-focused parlays include Matthew Stafford, Puka Nacua, Kyren Williams and Blake Corum. Available bets include touchdown scorer props and first-drive passing, receiving and rushing markets.
Which 49ers players are featured in these parlays?
The 49ers-focused parlays include Brock Purdy, Christian McCaffrey and Mike Evans. The available cards include touchdown scorer bets and first-drive passing, receiving and reception props.
Can the odds for these Rams vs. 49ers parlays change?
Yes. Odds and available markets can change before kickoff, so check DraftKings Sportsbook for the latest numbers before placing a bet.
