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Real Madrid vs. Man City prediction, pick for Wednesday 12/10/25

Real Madrid vs. Man City prediction, pick for Wednesday 12/10/25

Published:

By: Ciaran Doyle

The 2025/26 UCL league phase continues on Wednesday as two heavyweights clash in Madrid. This is the best game of this week’s Champions League slate, and it’s become a common fixture. Wednesday will mark the seventh time these two sides have matched up since 2023.

Man City are slight +130 favorites on DraftKings Sportsbook for this one, with a draw available at +290. Real Madrid are listed at +180 to win the game.

Real Madrid vs. Man City Prediction, Pick

There is a common theme when these two teams meet: goals. Four or more goals have been scored in four out of the last five games between these teams. In total, there have been 21 goals scored over those meetings, averaging out to 4.2 per contest. I don’t see why Wednesday’s game would be any different with some of the best attacking talent in the world on display.

Real Madrid are the second-highest scorers in La Liga, netting 32 times in their opening 16 league games. In the Champions League, they’ve scored 12 times in only five games.

Man City are the highest-scoring team in the Premier League so far this season, with 35 goals in 15 matches. They’ve been slightly less clinical in Europe than Madrid, scoring 10 times so far in this campaign.

Both teams have a track record of scoring goals in this fixture, but also this season.

Both sides have flaws defensively, which will only help this bet. Madrid are in a three-way tie for the second-best defensive league record, while four Premier League teams have conceded fewer times than Man City this season. Both teams have allowed five goals in their respective Champions League games this season, and three teams have conceded fewer. Keep in mind that half the teams in the competition have played an extra game after Tuesday’s slate.

There are goals to be had in this one, and defensive errors to be made as well. Buckle up and get your popcorn ready for this one. We should be in for a thriller.

The Pick: Over 3.5 Total Goals (+115)

Ciaran has been an editor for the DraftKings Network team since 2023. He graduated from the University of Arizona before attending Arizona State University for his master’s degree in sports journalism. Ciaran previously covered Phoenix Rising FC for Cronkite News before joining DraftKings. He is passionate about sports betting, and his biggest focus has always been on the NFL and soccer. You can find him on X at @Ciaran_Doyle7.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user (my username is ciarandoyle77) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.