Sunday’s clash between the San Francisco 49ers and the Arizona Cardinals has heavy implications for the NFC West race. The Niners, Rams and Seahawks are all within a couple of games of one another, while the Cardinals trail behind. As the Niners try to gain ground and the Cardinals try to stay alive, the player prop market for this game carries a lot of juice.
The 49ers enter as 3.5-point road favorites on DraftKings Sportsbook, while the Cardinals are listed as +164 underdogs. The game’s total is set at 48.5 points. Here are my top player props for Sunday’s Week 11 matchup between the 49ers and Cardinals.
Best 49ers vs. Cardinals Player Prop Bets
Jacoby Brissett 25+ Rushing Yards +153
Injuries have taken a serious toll on this 49ers defense. No absence means more than Fred Warner’s. In its last three games, San Francisco has surrendered 100+ yards on the ground, averaging 133.3. Running quarterbacks in particular have given the 49ers a lot of trouble. Enter Arizona backup Jacoby Brissett.
Just look at the last matchup between these two. Kyler Murray scampered for 37 yards on six carries, and that was with Warner in the lineup. Brissett isn’t the same level of runner, but he’s more than capable of breaking containment and picking up chunk gains.
Christian McCaffrey 50+ Receiving Yards -107
This is basically free money at this point. So far, San Francisco’s offensive linchpin has gone for 50+ receiving yards in nine of his first 10 games. He’s on pace to lead the 49ers in rushing and receiving yards, a feat no other player has accomplished. I see no reason why this game should be any different. Even with Brock Purdy back under center and Ricky Pearsall in the lineup out wide, the volume will be there for CMC. Expect another strong receiving day.
