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Tottenham vs. Villarreal prediction, pick for Tuesday 9/16/25

Tottenham vs. Villarreal prediction, pick for Tuesday 9/16/25

Published:

By: Charlie Cummings

Get ready for the first day of UEFA Champions League action. We have a lot of star-studded action on Tuesday to begin the league stage of the UCL, including a tie between Tottenham and Villarreal. It’s time to see who can make noise in Europe.

Tottenham are -115 favorites on DraftKings Sportsbook for this one, with a draw available at +265. If you favor a Villarreal upset, they are +300 on the moneyline. Let’s dig into a pick and prediction for Tottenham vs. Villarreal.

Tottenham vs. Villarreal Prediction, Pick

It’s been a strong start to the Tottenham season under Thomas Frank. They’ve won three of their first four Premier League contests, displaying considerable attacking prowess. Behind new signing Mohammed Kudus, plus holdovers Richarlison and Brennan Johnson, they have offensive firepower that can take over any game. And they certainly know how to do it in style.

Although Tottenham won the Europa League, their 2024/25 season was otherwise disappointing. A strong campaign in the Premier League and UCL would bring back confidence that Tottenham can be a competitive European club once again.

Behind star winger Nicolas Pepé, Villarreal have had a strong start to their La Liga season. They have finished between fourth and eighth in 11 of their last 12 campaigns, having yet to crack true contention. If their attacking prowess can be sustained, it could be a productive season for the Spanish side.

The work will be cut out for these defenses. Tottenham’s attacking power has caused problems for a few English clubs this year, while Pepé’s top form makes Villarreal’s attack a force to be reckoned with. There are bound to be a few high-scoring affairs on the docket for Tuesday, and this match will be one of them. Count on these attacks to deliver.

The Pick: Over 2.5 Total Goals (-135)

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