Our computer model projects a victory for the San Francisco 49ers when they play the Arizona Cardinals at Levi’s Stadium on Sunday, Oct. 6 at 4:05 p.m. ET — for more information regarding the spread, over/under and final score, continue reading.
Sign up for DraftKings Sportsbook and place your bets today!
49ers vs. Cardinals Predictions
- Our pick to win on the moneyline in this game is the 49ers, by a final score of 49ers 31, Cardinals 18.
- Against the spread, we expect that 49ers will cover. The spread is currently 49ers -7.5.
- As for the total, we see this one going under the posted over/under of 50 points.
49ers vs. Cardinals Odds
- Spread favorite: 49ers (-7.5)
- Moneyline: 49ers (-355), Cardinals (+280)
- Total: 50 points
49ers Betting Trends
- The 49ers have covered the spread twice in four opportunities this season.
- San Francisco is 1-0 against the spread so far when playing as at least 7.5-point favorites.
- Games involving the 49ers have gone over in three of their four games with a set total (75%).
- The 49ers have won 50% of the games this season when they were favored on the moneyline (2-2).
- San Francisco has played as a moneyline favorite of -355 or shorter in only one game this season, which it won.
Cardinals Betting Trends
- The Cardinals are 2-2-0 against the spread this year.
- Cardinals games have hit the over in three out of four opportunities (75%).
- The Cardinals have lost both games they’ve played as underdogs this season.
- Arizona has not entered a game this season with longer moneyline odds than +280.
Place your NFL bets online at DraftKings Sportsbook today!
49ers Key Stats
- Total offense: 413.3 yards per game, second in NFL
- Passing offense: 271.5 yards per game, second in NFL
- Rushing offense: 141.8 yards per game, eighth in NFL
- Total defense: 295.3 yards per game, ninth in NFL
- Passing defense: 199 yards per game, 15th in NFL
- Rushing defense: 96.3 yards per game, sixth in NFL
Cardinals Key Stats
- Total offense: 333 yards per game, 13th in NFL
- Passing offense: 179.8 yards per game, 25th in NFL
- Rushing offense: 153.3 yards per game, fifth in NFL
- Total defense: 354.8 yards per game, 24th in NFL
- Passing defense: 208.3 yards per game, 17th in NFL
- Rushing defense: 146.5 yards per game, 27th in NFL
This article contains AI-generated editorial insights provided by Data Skrive.
Place your NFL bets at DraftKings Sportsbook and bet online by downloading the DraftKings Sportsbook app.
Refine your research with the DraftKings Sportsbook’s Stats Hub!
From Consistency Sheets and Matchup Tools to System Tools and Player Splits, the DraftKings Sportsbook Stats hub features tools to help with your betting research!
The Crown Is Yours: Sign up for DraftKings and experience the ultimate host for games and betting experiences!
All odds provided by DraftKings Sportsbook and all odds subject to change.
DraftKings promoters may sometimes play on personal accounts in the games that advice is offered on. Personal views on the games and strategies above do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. DraftKings promoters may also deploy different players and strategies than what is recommended above. DraftKings promoters do not have access to any non-public information.