There are some fantastic games on the Week 10 NFL slate.
With plenty of ways to get in on the action on DraftKings Sportsbook, here are my best bets for Sunday.
NFL Week 10 Best Bets: Expert Picks, Predictions and Analysis
Seahawks & Ravens Moneyline Parlay (+100)
The Seahawks should get the win in Las Vegas on Sunday. It will be Fernando Mendoza’s first career start, and this is a really tough opponent for the No. 1 pick. Mike Macdonald is one of the best defensive minds in football, and this Seattle defense ranks top-five in the NFL in EPA/play and success rate. They should throw a lot of things at Mendoza that he has not seen before, and that should lead to mistakes from the reigning Heisman Trophy winner.
Seattle held two of its past three opponents to just three points. With that level of defensive dominance, Drew Lock just needs to be a game manager. That is exactly what he did last week against the Cardinals. While the upside with Lock is lower than it is with Sam Darnold, he is taking far fewer risks and therefore not turning the ball over the way that Darnold was. Lock should play smart and get enough points on the board to win as his defense dominates the rookie quarterback.
The Chargers are a complete disaster. Justin Herbert seems completely broken and leads the league in interceptions thrown. To make matters worse, Herbert now has an injury to his left middle finger. While it’s not his throwing hand, it could affect Herbert on snaps and when scrambling with the ball, which could lead to even more turnovers. The Los Angeles offense now ranks dead last in the NFL in EPA/play and 31st in success rate. It’s hard to see them going on the road to Baltimore and scoring a lot of points.
Meanwhile, Jacoby Brissett will make his first start as a Raven in this game. It will be hard for the Chargers to prepare defensively with no tape on how Brissett operates in this offense. Brissett already beat the Chargers earlier this season with Arizona, and should beat them again with a second team.
CeeDee Lamb Anytime TD (-130)
CeeDee Lamb is having a brilliant season for the Cowboys. After George Pickens had a career year last season, it is now Lamb on pace to be one of the NFL’s top receivers this season. He ranks inside the top three in the NFL in receptions, receiving yards and receiving touchdowns. Lamb has seven touchdown grabs this season, including three in his past three games. He has a great chance to add another touchdown to that tally this week against the 49ers.
This game has all of the makings of a shootout. The 49ers are a bit banged up in the secondary, and the Dallas offense at home is always deadly. Both of these teams rank inside the top six in the NFL in offensive EPA/play. It should be a back-and-forth scoring fest, which would lead to plenty of scoring opportunities for CeeDee Lamb. The last time Lamb faced the 49ers was in 2024, a game where he had 13 catches for 146 yards and two touchdowns.
The 49ers rank 31st in the NFL in opponent passing touchdown percentage, with 73.3% of their opponent touchdowns coming through the air. When the Cowboys get into the red zone, Dak Prescott should be looking CeeDee Lamb’s way. Lamb should improve on his excellent season by scoring at least once in this game.
Six-Point Teaser: Panthers +8.5 & Bills -2.5
The Panthers should be able to keep it close in New Orleans in this NFC South battle. Both of these defenses have been shaky this season, but the Panthers have been much better on offense. Carolina ranks 13th in the league in offensive EPA/play, while the Saints rank 22nd. The Saints have not had much of a home-field advantage this season either. They are 1-4 at home this season, with the one win coming last week against the Browns by one point after Cleveland failed on a game-winning two-point conversion attempt. Of the Saints’ three wins this season, none have been by more than seven points. The Panthers should hang in this game the whole way and have a great chance to win it outright.
The Bills should take care of business in this matchup against the Jets. This is a big spread on the road in the division, so teasing the Bills down to -2.5 is the right way to back them. The Jets are not a terrible team, but they have no clue how to win football games. They have been competitive in a lot of games this year where they just make one or two wrong plays that decide the game. That is a bad recipe when facing Josh Allen, who might be the best player in the NFL at clawing out a win by making one or two big plays for his team. This could be a tight game for three and a half quarters, but it’s hard to imagine Josh Allen not going down and getting the score he needs to win or seal the game against the Jets.
