Fantasy Football Start ‘Em, Sit ‘Em Week 10 Picks

Week 10 of the 2026 NFL season has arrived! As the year continues, more injuries pile up around the league, setting the stage for tough lineup decisions for all fantasy managers. Let’s break down my fantasy football start/sit Week 10 picks for the 2026 season.

Week 10 Fantasy Football Start/Sit Picks

QB Start/Sit Week 10

Start: Bryce Young at Saints

When the Panthers’ offense gets rolling, there aren’t many better units in the league, and that was the case last week against a very good Broncos defense. Carolina wasn’t able to pull out the win, but Bryce Young bounced back in a huge way after a pair of disappointing consecutive contests.

The former No. 1 overall pick diced up the Denver secondary, completing 28 of 39 attempts for 276 yards and three touchdowns, good enough for 21.3 fantasy points. Young should keep the momentum rolling in a much more favorable matchup against the Saints, who allow the fifth-most passing yards per game. Fire up Young as a QB1 once again.

Sit: Matthew Stafford at Cardinals

Matthew Stafford still saw a start percentage north of 50% across major fantasy platforms last week, to which I ask… why? The rare ceiling performance just isn’t worth the mediocre floor. Stafford has failed to amass 20 points since Week 5, scoring fewer than 13 in back-to-back games.

On paper, the Cardinals are a very favorable matchup for the veteran, but it’s impossible to trust someone putting up such lackluster numbers despite his litany of offensive weapons. Now, that last part may not even be the case anymore, as Puka Nacua could be set to miss time with a knee injury. With or without his top weapon, there are better options out there at QB in Week 10.

WR Start/Sit Week 10

Start: DeMario Douglas at Lions (Germany)

The Patriots may be struggling as a whole, but DeMario Douglas has certainly answered the call in the wake of multiple key injuries in New England’s receiving corps. The shifty slot specialist has now scored at least 15 PPR points in four of his last five outings, stepping up with A.J. Brown, Romeo Doubs and Mack Hollins all missing various contests over that stretch.

Douglas hauled in five of nine targets last Sunday against the Packers for 102 yards, once again pacing the Pats’ receiving room. Next up, he draws the Lions, who have been pretty mediocre against the position. Even if A.J. Brown does return to the lineup —which doesn’t seem likely— you can fire up Pop as a dependable WR3/FLEX with upside.

Sit: Tre Tucker vs. Seahawks

There are a couple of defenses you just don’t mess with from a fantasy perspective if you can help it. The Seahawks are one of them.

Once again, Seattle is stymieing opposing passing attacks at an elite level. Mike Macdonald’s squad is surrendering the fewest fantasy points to receivers per game, which doesn’t bode well for Vegas’ top WR this week. Tre Tucker has flashed high fantasy upside consistently this year, but the floor is still quite porous. After back-to-back outings with at least 21 PPR points, he has scored a combined 9.5 in the two subsequent games.

You can tell where this is going. A volatile receiver combined with a horrendous matchup isn’t a recipe for success. Keep Tucker on your bench in Week 10.

Find all of our Week 10 fantasy football advice and content here!

RB Start/Sit Week 10

Start: Zach Charbonnet at Raiders

It only took two games for Zach Charbonnet to get back up to speed. Last week, I declared that when both Charbonnet and Jadarian Price were healthy, I expected the former to take on about 65% of the carries. That appears to be the plan, as the dynamic fourth-year back rushed 16 times for an uber-efficient 77 yards, also hauling in one catch.

It’s only a matter of time before Charbonnet finds the end zone, and an enticing matchup with the Raiders could be the perfect opportunity to do so. Las Vegas allows the fifth-most fantasy points to running backs per game, putting Charbonnet firmly in RB2/FLEX territory just a few games into his return from a serious knee injury.

Sit: Tyler Allgeier vs. Rams

Tyler Allgeier is going to see plenty of touches. The question is, can he translate them into production?

In the three outings this season in which Allgeier saw at least 17 carries as the lead back, he has rushed at a horribly inefficient clip. Just last week against Seattle, the fifth-year back only managed 46 yards on a measly 2.7 yards per attempt. It isn’t going to get much better against the Rams in Week 10.

L.A. boasts a top-10 run defense that just reintroduced superstar Myles Garrett into the fold. It’s hard to imagine Allgeier finding much success on the ground, putting him in touchdown-or-bust territory. Sit him if you can afford to.

TE Start/Sit Week 10

Start: Darren Waller at Saints

Waller has been relatively volatile this season from a fantasy perspective, but when the Panthers’ offense is firing on all cylinders, it typically translates to production for him. As I highlighted in Bryce Young’s section as my QB start of the week, I expect that to be the case on Sunday against the Saints.

Waller put up a ridiculous eight receptions for 90 yards and a touchdown against the Broncos, returning to elite form that the 34-year-old flashes every now and then. He’ll look to keep the momentum rolling against a vulnerable Saints defense. Fire Waller up as a low-end TE1 with obvious upside.

Sit: Kyle Pitts vs. Chiefs

In fantasy football, Kyle Pitts giveth, and Kyle Pitts taketh away.

Lately, though, it’s mostly just been “taketh away” territory. Pitts strung a productive three-week stretch together early on, but has been nowhere to be seen in back-to-back outings for the Falcons. The sixth-year tight end has racked up a combined meager eight points over the last two weeks, and will now take on the Chiefs, who boast one of the best defenses in football.

It’s safe to say Pitts is in touchdown-or-bust terrain heading into this contest, and I’d lean heavily towards the “bust” side of that scale given the matchup.

Those are my Week 10 fantasy football start ’em, sit ’em picks! Stay tuned for positional WR and RB 2026 Week 10 start/sit picks and advice later this week.