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Monday Night Football Parlay Trends: Buffalo Bills vs. Los Angeles Rams 10/12/26

Monday Night Football Parlay Trends: Buffalo Bills vs. Los Angeles Rams 10/12/26

NFL Sports Betting Picks DraftKings Sportsbook Insights

Published:

By: Sam Connon

With the 2026 NFL season underway, DraftKings is back with a tool to help you build the ultimate parlay. Start by selecting one pick – an “Anchor” bet – and choose how many legs you want. Then, the Free Trending Parlay Picks Optimizer will give you a custom parlay based on games in which the Anchor bet has previously won.

The Buffalo Bills and Los Angeles Rams are set to face off in the final game of Week 5, going head-to-head on Monday Night Football. DraftKings Sportsbook has Los Angeles pegged as a 3.5-point favorite at home. Buffalo is looking to shake off a surprising loss to the New England Patriots that broke up their previously perfect record. Los Angeles, meanwhile, is sitting at 2-2 after staging a fourth quarter comeback against the Philadelphia Eagles.

If you feel good about the Bills pulling off the upset on Monday night, here is a fresh NFL SGP Anchor via the Free Trending Parlay Picks Optimizer.

  • Buffalo Bills moneyline (+150)
    • Josh Allen under 20.5 pass completions (-109)
    • Josh Allen under 32.5 pass attempts (-102)
    • Dawson Knox under 11.5 receiving yards (-107)
    • Khalil Shakir under 4.5 receptions (-129)

Combined Odds: +850

Creating a parlay with the appropriate angles on the specific totals listed above would have hit in each of Buffalo’s three wins so far this season. So, instead of simply picking Bills moneyline at +150, you can ride these additional trends on Monday versus the Rams.

On the other side of the contest, picking running back Kyren Williams to score a touchdown could be a smart play considering he has done so in six of his last seven games dating back to last postseason. The Free Trending Parlay Picks Optimizer has run the numbers on that pick’s past success as an NFL SGP Anchor, as well.

  • Kyren Williams anytime TD (-155)
    • Kyren Williams 80+ rushing yards (+141)
    • Blake Corum over 3.5 receiving yards (-115)
    • Matthew Stafford 300+ passing yards (+129)
    • LA Rams -3.5 (-102)

Combined Odds: +1700

Creating a parlay with the appropriate angles on the specific totals listed above would have hit the last two times that Williams found the end zone. Keep these trends in mind if you’re confident in Williams finding paydirt Monday night.

To see all DraftKings betting analysis, head over to the DraftKings Network sports betting picks page!

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Sam Connon
Sam joined DraftKings in 2025 following five years with Sports Illustrated’s “On SI” network. He has covered the UCLA Bruins, New England Patriots, Tampa Bay Rays, MLB, MiLB and NBA, on top of earning awards from the Society of Professional Journalists and College Media Association during his time as a student at UCLA.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.