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New York Mets at Chicago White Sox prediction, pick for Friday 8/21/26

New York Mets at Chicago White Sox prediction, pick for Friday 8/21/26

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By: Griffin Wong

Every city with multiple franchises in the same sport has a marquee franchise and a scrappier one with a chip on its shoulder. That doesn’t mean the marquee team necessarily has to be more successful every season, but in 2026, that’s been the case: the New York Yankees have a better record than the New York Mets, the Chicago Cubs are better than the Chicago White Sox, and the Los Angeles Dodgers are better than the Los Angeles Angels.

Tonight, New York and Chicago’s secondary teams will begin a three-game series with a 7:40 p.m. ET meeting. The overachieving White Sox are currently in the division lead, while the Mets, despite a late charge, still look set to finish with one of the National League’s worst records.

In tonight’s series opener, Sean Manaea will start for New York, and Sean Burke will toe the rubber for Chicago.

Let’s break down this showdown of the Seans with some odds and lines at DraftKings Sportsbook.

New York Mets at Chicago White Sox Best Bets

  • Chicago White Sox Race to 3 Runs (-115): In a battle between Seans, I prefer Burke to Manaea. Burke has a 2.04 ERA across the last two months, and while the Mets’ offense is in slightly better form than the White Sox’s, Chicago has gotten to three runs first in three of its past four games.
  • Sean Burke 8+ Strikeouts (+227): Burke has an 81st-percentile strikeout rate, and New York has registered the ninth-most strikeouts over the last 30 days. He’s struck out eight or more batters nine times in 25 appearances, making +227 excellent value.

New York Mets at Chicago White Sox prediction, preview

New York has wasted another season of Juan Soto’s prime, suffering a losing streak early in the season that effectively took it out of playoff contention for the second straight season. Both of the Mets’ major offseason acquisitions, Bo Bichette and Marcus Semien, have been extremely disappointing, and as a result, New York has had the fifth-worst offense this season despite posting the ninth-best mark since the All-Star break. At least Carson Benge has been a standout rookie. The Mets have had more pitching bright spots, posting the fifth-lowest ERA since the Midsummer Classic, as Nolan McLean, Christian Scott, and Zac Thornton have been pretty solid. New York completely reworked its staff at the deadline, trading away starters Freddy Peralta, Clay Holmes, and David Peterson and relievers Huascar Brazobán, Luke Weaver, and Brooks Raley, but so far, their less-heralded replacements (Daniel Duarte, Nate Lavender, and Jefry Yan in particular) have been tremendous. Despite all of their offseason missteps, the Mets have some potential pieces in place.

The White Sox have been the season’s surprise package. Two years after finishing with 121 losses, Chicago is 66-61, owning a 3.5-game lead over the Minnesota Twins and a 63.8% chance of ultimately qualifying for the postseason, per FanGraphs. Though the White Sox have dipped back towards league-average since the Midsummer Classic, they have the 12th-best offense in baseball for the season as a whole, as despite Munetaka Murakami’s recent slump, he still forms the core of a very promising young infield with Chase Miedroth, Colson Montgomery, and Miguel Vargas. Additionally, Chicago has had an above-average pitching staff as of late, including a top-10 bullpen for the season as a whole. Burke and Anthony Kay have formed a solid one-two punch at the top of the rotation, and although trade deadline acquisitions Luis Castillo and Brazobán haven’t been great, the White Sox have a couple of encouraging bullpen pieces as well, including 24-year-old Grant Taylor, who hasn’t given up a run since July 2.

Manaea had a rough start to the season out of the bullpen, pitching to a 5.56 ERA through the end of May, but after being deployed for length at the start of June (first as a bulk reliever behind a one-inning opener and then as a full-time starter), he’s registered a 3.62 mark. In that span, he’s given up three or fewer earned runs in all but one of his starts. Advanced stats aren’t too kind to him overall, though; he’s recorded a 30th-percentile xERA and ranks in only the 15th percentile in pitching run value. He has done an above-average job both striking out batters and avoiding walks, and the White Sox are somewhat of a three-true-outcomes team. The issue is that he has done a poor job generating whiffs, mitigating one of Chicago’s biggest weaknesses. He’s been prone to giving up hard hits and barrels, a bad recipe against one of baseball’s more powerful lineups, though at least he has the platoon advantage against Murakami. The location splits are mixed; Manaea has been slightly more effective on the road, but the White Sox have been better at home.

Burke has been Chicago’s best pitcher this season, but he is coming off of one of his worst starts, a 4.1-inning, four-run outing against the Detroit Tigers. Overall, though, he’s trending in the right direction, as across his last 11 starts, dating back to June 18, he’s pitched to a 2.04 ERA. Advanced numbers suggest that he should have a pretty significant edge in the starting pitching matchup; he sports a 69th-percentile expected ERA and 88th-percentile pitching run value, and his only notable weakness is his tendency to give up fly balls, something New York does at a below-average rate as is. Burke has a top-quintile strikeout rate, and the Mets strike out a lot, including the ninth-most times across the last 30 days (most of which have come without Soto, who’s out with a calf strain). He does rank in the 39th percentile in average exit velocity, and New York has a hard-hitting lineup, but Soto’s absence takes some of the punch out of it, so I’d expect Burke to be fine. The location splits are negligible, as both he and the Mets have performed similarly regardless of venue.

New York Mets at Chicago White Sox pick, best bet

Best Bet: Chicago White Sox Race to 3 Runs (-115)

Manaea is a decent pitcher in strong form, and New York’s strong defense should allow him to avoid too much damage, but it’s hard to ignore Burke’s numbers over the last two months.

Strong Lean: Sean Burke 8+ Strikeouts (+227)

I’m not sure if venue really makes that much of a difference in strikeout count, but it’s worth noting that Burke has notched at least eight strikeouts in each of his last four home starts, and given that the Mets have struck out a ton since losing Soto, that’s worth the +227 odds.


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Griffin Wong has been a content writer at DK Network since November 2024. Prior to that, he was the former sports editor for the Harvard Crimson, where he covered the football team for two years and earned four Story of the Year nominations from the Associated College Press. A lifelong Lakers and Dodgers fan, Griffin’s favorite athlete of all time is Kobe Bryant. When he’s not writing, Griffin is usually skiing, running, golfing, or playing basketball — badly.
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I am a promoter at DraftKings and am also an avid fan and user and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.