Every week, DraftKings Network analysts share their favorite NFL bets on DraftKings Sportsbook for each NFL game.
Below is a collection of the top NFL best bets for the Week 10 NFL Sunday slate.
To see all DraftKings betting analysis, head over to the DraftKings Network sports betting picks page!
Check out the numerous NFL betting markets available on DraftKings Sportsbook!
Brendan O’Sullivan: Ravens vs. Vikings Best Prop Bets
Lamar Jackson under 27.5 pass attempts (-114)
J.J. McCarthy under 31.5 pass attempts (-121)
Justin Jefferson over 72.5 receiving yards (-113)
Read Brendan’s full betting analysis here: NFL Best Bets: Ravens vs. Vikings Best Prop Bets for Week 10
Ryan Wohl: Buffalo Bills vs. Miami Dolphins prediction, pick
Buffalo Bills -9.5 vs. Miami Dolphins (-112)
Read Ryan’s full betting analysis here: Buffalo Bills vs. Miami Dolphins prediction, pick for NFL Week 10 on Sunday 11/9/25
Cooper Albers: Patriots vs. Buccaneers Best Prop Bets
Drake Maye 2+ Pass TDs (-148)
Emeka Egbuka Anytime TD (+105)
Baker Mayfield Under 15.5 Rush Yards (-114)
Read Cooper’s full betting analysis here: NFL Best Bets: Patriots vs. Buccaneers Best Prop Bets for Week 10
Dan Johnson: San Francisco 49ers vs. Los Angeles Rams prediction, pick
Rams -5.5 (-115) at 49ers
Read Dan’s full betting analysis here: San Francisco 49ers vs. Los Angeles Rams prediction, pick for NFL Week 10 on Sunday 11/09/25
Dan Johnson: Seattle Seahawks vs. Arizona Cardinals prediction, pick
Seahawks vs Cardinals u45.5 total points (-105)
Read Dan’s full betting analysis here: Seattle Seahawks vs. Arizona Cardinals prediction, pick for NFL Week 10 on Sunday 11/09/25