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NFL Betting Cheat Sheet: Best Bets, Picks, Props for Raiders vs. Cowboys on Week 16 Monday Night Football

NFL Betting Cheat Sheet: Best Bets, Picks, Props for Raiders vs. Cowboys on Week 16 Monday Night Football

Los Angeles Chargers Sports Betting Picks NFL DraftKings Sportsbook Insights Rail

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By: DK.Network.Editors

Every week, DraftKings Network analysts share their favorite NFL bets on DraftKings Sportsbook for each NFL game.

Below is a collection of the top NFL best bets for Week 11 Monday Night Football between the 49ers and Colts.

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To see all DraftKings betting analysis, head over to the DraftKings Network sports betting picks page!

Check out the numerous NFL betting markets available on DraftKings Sportsbook!

Garion Thorne: First Touchdown Scorer

Jauan Jennings First Touchdown Scorer (+850)

Tyler Warren First Touchdown Scorer (+1600)

Read Brendan’s full betting analysis here: First Touchdown Scorer Prop Bets for 49ers vs. Colts on Monday Night Football

Sean Barnard: 49ers at Colts Best Prop Bets

Josh Downs Over 25.5 Receiving Yards (-114)

George Kittle Over 67.5 Receiving Yards (-113)

Jonathan Taylor Over 97.5 Rushing Yards (-114)

Read Sean’s full betting analysis here: NFL Best Bets: 49ers at Colts Best Prop Bets on Week 16 Monday Night Football

Dan Johnson: Indianapolis Colts vs. San Francisco 49ers prediction, pick

Best bet: 49ers -5.5 (-110) at Colts

Best prop lean: Tyler Warren 5+ receptions (+150)

Read Dan’s full betting analysis here: Indianapolis Colts vs. San Francisco 49ers prediction, pick for NFL Week 16 on Monday 12/22/25

DK.Network.Editors
Disclaimer

DraftKings promoters may sometimes play on personal accounts in the games that advice is offered on. Personal views on the games and strategies above do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. DraftKings promoters may also deploy different players and strategies than what is recommended above. DraftKings promoters do not have access to any non-public information.