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NFL Betting Cheat Sheet: Best Bets, Picks, Props for 49ers vs. Panthers on Week 12 Monday Night Football

NFL Betting Cheat Sheet: Best Bets, Picks, Props for 49ers vs. Panthers on Week 12 Monday Night Football

Los Angeles Chargers Sports Betting Picks NFL DraftKings Sportsbook Insights Rail

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By: DK.Network.Editors

Every week, DraftKings Network analysts share their favorite NFL bets on DraftKings Sportsbook for each NFL game.

Below is a collection of the top NFL best bets for Week 12 Monday Night Football between the 49ers and Panthers.

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To see all DraftKings betting analysis, head over to the DraftKings Network sports betting picks page!

Check out the numerous NFL betting markets available on DraftKings Sportsbook!

Alex Hunter: Best Brock Purdy prop bet

Best Bet: Brock Purdy U 9.5 Rushing Yards (-112)

Read Alex’s full betting analysis here: Brock Purdy best prop bet for 49ers vs. Panthers on Monday 11/24/25

Sean Barnard: Cowboys at Raiders Best Prop Bets

Christian McCaffrey Over 48.5 Receiving Yards (-114)

Bryce Young Over 209.5 Passing Yards (-112)

George Kittle Anytime Touchdown (+115)

Read Sean’s full betting analysis here: NFL Best Bets: Panthers at 49ers Best Prop Bets on Week 12 Monday Night Football  

Dan Johnson: San Francisco 49ers vs. Carolina Panthers prediction, pick

Best bet: Panthers +7.5 (-110) at 49ers

Best prop lean: Christian McCaffrey 6+ receptions (+110)

Read Dan’s full betting analysis here: San Francisco 49ers vs. Carolina Panthers prediction, pick for NFL Week 12 on Monday 11/24/25

DK.Network.Editors
Disclaimer

DraftKings promoters may sometimes play on personal accounts in the games that advice is offered on. Personal views on the games and strategies above do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. DraftKings promoters may also deploy different players and strategies than what is recommended above. DraftKings promoters do not have access to any non-public information.