DKNetwork Logo DKNetwork Logo
Best Nico Collins Prop Bets for Bills vs. Texans on Thursday 11/20/25

Best Nico Collins Prop Bets for Bills vs. Texans on Thursday 11/20/25

Updated:

By: Ciaran Doyle

Week 12 gets started in Houston as the Bills take on the Texans. These teams matched up last season, with Houston getting a 23-20 home victory. Can Nico Collins and Houston make it two wins in a row against Buffalo?

The Bills are 6-point favorites for this one, with the Texans +235 underdogs on the moneyline. The points total is set at O/U 43.5 on DraftKings Sportsbook.

Below is my favorite Collins prop bet on DraftKings Sportsbook for Thursday’s game.

Best Nico Collins Prop Bets on DraftKings Sportsbook

Nico Collins has gone over this total in each of his last three games. The common denominator in those last three? Davis Mills.

Mills entered after a C.J. Stroud concussion in Week 9 against Denver and ever since, he has gone to his star wideout early and often. Collins has received double-digit targets in each of his last three games while averaging 101 yards per contest.

The Bills’ secondary is no joke, however, ranking second in the NFL this season against the pass. That is likely the only reason why this total is only at 74.5, as Collins has received a ton of volume with Mills under center and will likely do so again on Thursday. It’s a tough matchup for Collins, but if he gets another 10+ targets, this total should be no problem.

Collins has played in nine games so far this season, going over this total five times. The possible game script could be helpful in this one too. Buffalo is a six-point favorite, and if they get out to a big lead, it will force Houston to throw the ball more than they would like.

Collins should go over this total for the fourth consecutive game.

Best Bet: Nico Collins Over 74.5 Receiving Yards (-111)

Ciaran has been an editor for the DraftKings Network team since 2023. He graduated from the University of Arizona before attending Arizona State University for his master’s degree in sports journalism. Ciaran previously covered Phoenix Rising FC for Cronkite News before joining DraftKings. He is passionate about sports betting, and his biggest focus has always been on the NFL and soccer. You can find him on X at @Ciaran_Doyle7.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user (my username is ciarandoyle77) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.