Every week, DraftKings Network analysts share their favorite NFL bets on DraftKings Sportsbook for each NFL game.
Below is a collection of the top NFL best bets for the Week 11 NFL Sunday slate.
To see all DraftKings betting analysis, head over to the DraftKings Network sports betting picks page!
Check out the numerous NFL betting markets available on DraftKings Sportsbook!
Cooper Albers: Packers vs. Giants Best Prop Bets
Josh Jacobs 90+ Rush Yards (+126)
Jameis Winston 230+ Pass Yards (+107)
Romeo Doubs Anytime TD Scorer (+220)
Read Cooper’s full betting analysis here: NFL Best Bets: Packers vs. Giants Best Prop Bets for Week 11
Charlie Cummings: San Francisco 49ers vs. Arizona Cardinals Prediction, Pick
Over 48.5 Total Points -108
Read Charlie’s full betting analysis here: San Francisco 49ers vs. Arizona Cardinals Prediction, Pick for NFL Week 11
Brendan O’Sullivan: Vikings vs. Bears Prop Bets
J.J. McCarthy over 0.5 interceptions (-150)
Justin Jefferson over 73.5 receiving yards (-112)
D’Andre Swift over 58.5 rushing yards (-112)
Read Brendan’s full betting analysis here: NFL Best Bets: Vikings vs. Bears Best Prop Bets for Week 11
Dan Johnson: Los Angeles Rams vs. Seattle Seahawks prediction, pick
Rams vs. Seahawks u48.5 points (-110)
Read Dan’s full betting analysis here: Los Angeles Rams vs. Seattle Seahawks prediction, pick for NFL Week 11 on Sunday 11/16/25
Dan Johnson: Buffalo Bills vs. Tampa Bay Buccaneers prediction, pick
Bills -5.5 (-115) vs. Buccaneers
Read Dan’s full betting analysis here: Buffalo Bills vs. Tampa Bay Buccaneers prediction, pick for NFL Week 11 on Sunday 11/16/25