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New Orleans Saints vs. Carolina Panthers prediction, pick for NFL Week 10 on Sunday 11/9/25

New Orleans Saints vs. Carolina Panthers prediction, pick for NFL Week 10 on Sunday 11/9/25

Published:

By: Charlie Cummings

In recent memory, it feels like the Saints and Panthers have revolved around one another in the NFC South. When one rises, the other falls. The Carolina Panthers find themselves above .500 and firmly in the playoff race at 5-4, while the New Orleans Saints have the worst record in the NFC at a brutal 1-8. Let’s see if the cycle continues on Sunday.

Carolina is a 5.5-point home favorite and -245 on the moneyline, while New Orleans is +200 on DraftKings Sportsbook. The game total is set at 38.5 points. Let’s dig into a preview and prediction for this Saints-Panthers contest.

Saints vs. Panthers Preview

Saints games have become considerably more interesting now that Tyler Shough is under center. I’m not quite sure if that’s complimentary or derogatory yet. Much like the quarterback he replaced, Spencer Rattler, Shough is capable of some fantastic throws. He’s also capable of some rough moments.

Things are going to get worse for the Saints before they can get better. The question is how much worse they can get.

Carolina has QB problems as well. Bryce Young continues to struggle — but the team keeps winning. Their run game looks incredible, fueled by surprise breakout running back Rico Dowdle. This team continues to find ways to win close games, thanks to strong special teams, timely defensive plays, and effective ball control by the offense.

Saints vs. Panthers Pick, Best Bet

On one hand, you have a team desperately trying to win. Carolina wants to get the stink of the past few years off of them, and a Wild Card berth would go a long way towards rebuilding goodwill with the fans.

On the other hand, you have a team outwardly trying to lose. The Saints, already stumbling through the season, dealt away even more pieces at the deadline. It’s a race to the bottom for New Orleans, and the Panthers stand to benefit from that.

Best Bet: Carolina Panthers -5.5 Points (-108)

I am a promoter at DraftKings and am also an avid fan and user and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.