Perhaps it’s a little morbid, but what else do fantasy managers and the football-gaming/-fandom republic fear more than the bottom falling out from under their teams before Week 1 even ends? In the case of Christian McCaffrey owners, the structural integrity of the floor is feeling awfully shaky—and awfully familiar—before the first Sunday of the season. A.J. Brown owners might be scrambling (indeed, I had someone send me a screenshot of a trade they made for AJB in a dynasty league during the lightning delay last night). Even Xavier Worthy didn’t survive the first Chiefs drive. And, of course, there’s always the terrible and seemingly exponentially-greater-than-ever-before shot your star players and early fantasy draft picks might give you reason, during Week 1, to wonder if your roster is sustainable as is. Fear not! Once more, I’m here with the full gamut of my Five Lists of Five: Week 1 edition (2025) to get you set with sleepers, stash players, matchups to exploit, and must-starts. This way you can both win and bulwark your bench for the carnage to come.
You know how it goes. We’re in the business of domination, here. We trade in wins, and wins only. We, like Billy Beane, loathe losing more than we wish for winning. And so, below, I’ve got a mix of analysis that should help you maximize your Week 1 fantasy football lineups, but also shore up your bench with potential cosmic storms waiting to happen.
Find links to all below, and enjoy laying waste to the most beloved of your leaguemates.
Follow my handle @dansby_edits for all of my fantasy football content—as well as plenty of NFL and College Football betting goodies—all season long.
Dan Johnson’s Fantasy Football Five Lists of Five: Week 1 edition (2025)
I’ve gone ahead and added the names of the players included on each list, so as to make this document more useful going forward. Having said that, if you want any of the analysis as to why I consider these players worthy of a particular list, head to the article itself.
Top five must-start players for Week 1 of fantasy football 2025 (link)
- Tucker Kraft, TE, Green Bay Packers
- Kyle Pitts, TE, Atlanta Falcons
- Jaylen Waddle, WR, Miami Dolphins
- Marvin Harrison Jr., WR, Arizona Cardinals
- Isiah Pacheco, RB, Kansas City Chiefs (played 9/5/25)
Top five running back sleepers for Week 1 of fantasy football 2025 (link)
- Ollie Gordon II, Miami Dolphins
- Woody Marks, Houston Texans
- Damien Pierce, Houston Texans
- Kendre Miller, New Orleans Saints
- Kyle Monangai, Chicago Bears
Top five wide receiver sleepers for Week 1 of fantasy football 2025 (link)
- Jayden Higgins, Houston Texans
- Jordan Whittington, Los Angeles Rams
- Dont’e Thornton, Las Vegas Raiders
- Isaac TeSlaa, Detroit Lions
- Keon Coleman, Buffalo Bills
Top five WR/CB matchups to target in Week 1 fantasy football 2025 (link)
- Nico Collins, Houston Texans (vs. Rams)
- Chris Olave, New Orleans Saints (vs. Cardinals)
- Jakobi Meyers, Las Vegas Raiders (vs. Patriots)
- Matthew Golden, Green Bay Packers (vs. Lions)
- Tetairoa MacMillan/Xavier Legette, Carolina Panthers (vs. Jaguars)