Stanford and Louisville kickoff on Saturday afternoon at 3:15pm ET. The home Cardinals are priced as a massive 22.5-point home favorite on DraftKings Sportsbook, with a high total set at 60.5. Here’s my prediction and best bet for the matchup.
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| Spread | Louisville -22.5 |
| Moneyline | Louisville -2100/Stanford +1100 |
| Total | 60.5 |
| Prediction | Stanford 10 – Louisville 48 |
| Best Bet | Louisville Team Total OVER 40.5 |
Stanford vs. Louisville prediction
Louisville took a couple of tough three-point losses in ACC play to Wake Forest and NC State, but still aren’t completely out of it. The Cardinals responded with wins over FSU and Syracuse. Now they come out of the bye week in a spot they can smash Stanford.
Stanford might as well have just stayed home when its had east coast trips this season — 35-7 at Duke, 57-3 at Wake Forest and 58-7 at Notre Dame. Pick Six Previews actually ranks Louisville No. 1 in opponent-adjusted offense, and the rushing attack ranks No. 1 overall as well. Off a bye against one of the worst teams in Power 4 that has performed historically terrible on east coast trips, I expect the Cardinals to name their score here.
Louisville dropped 44 on FSU, 41 on SMU and got to 38 against a solid SEC defense in Ole Miss. Getting into the 40’s here with a bunch of explosive plays feels likely.
Stanford vs. Louisville best bet
I’m torn between laying the points and the team total on Louisville. Ultimately, I sided to play the team total over, but will likely lay points as a smaller bet. Frankly, if anybody is scoring into the 40’s, it’s unlikely Stanford will be anywhere close. Especially since Stanford hasn’t topped seven points in any of its games out east this season.
CFB Best Bet: Louisville Team Total OVER 40.5 (-125)
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