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Prediction, pick for Yana Santos vs. Luana Santos at UFC Vegas 123

Prediction, pick for Yana Santos vs. Luana Santos at UFC Vegas 123

Published:

By: Cooper Albers

We’ve got a namesake duel on tap for Saturday night, as women’s bantamweights Yana Santos and Luana Santos collide at UFC Fight Night: Moicano vs. Nolan inside the Meta APEX. 

Yana Santos (17–8, 7–5 UFC) returns after a year away from the cage, looking to build on a three-fight winning streak capped by a unanimous-decision victory over Macy Chiasson at UFC 320 in October 2025. Luana Santos (11–2, 6–1 UFC) has also won three in a row, coming off a commanding decision over Karol Rosa in June. 

Luana Santos enters as a considerable -290 moneyline favorite on DraftKings Sportsbook. Yana Santos is a +235 underdog, with the fight total set at O/U 2.5 rounds.

Yana Santos vs. Luana Santos Fight Preview

Yana Santos (#6)

  • 17–8 (7–5 UFC)
  • 7–3(T)KO
  • 1–2 SUB

Yana Santos is back in action after a year-long layoff, and she returns with plenty of momentum. The Russian contender is riding a three-fight winning streak, scoring unanimous decisions over Chelsea Chandler, Miesha Tate, and, most recently, Macy Chiasson. “Foxy” is a formidable striker but has been vulnerable against strong grapplers, saddled with a 51 percent takedown defense. Now 36, she may struggle to keep things standing against high-level judoka Luana Santos.  

Luana Santos (#7)

  • 11–2 (6–1 UFC)
  • 1–0 (T)KO
  • 5–0 SUB

Luana Santos has quickly established herself as a serious title contender. At just 26, the Brazilian prospect has won six of her first seven UFC fights — including a three-fight surge since moving up to bantamweight in 2025. While not much of a threat on the feet, Santos holds a black belt in judo and will look to impose her explosive grappling from the opening bell. After submitting Tainara Lisboa in her 135-pound debut, she smothered Melissa Croden and Karol Rosa for a pair of one-sided decision wins. 

Yana Santos vs. Luana Santos Pick, Best Bet

In a fight where at least one Santos will get her hand raised, Luana Santos should get the nod. She enters the clash with Yana Santos with a decade-long age advantage and a clear path to taking the fight to the mat early and often. The most likely outcome is Luana Santos staying undefeated at bantamweight with a third straight decision win. But her dangerous submission arsenal could come in handy against an opponent who struggles on the ground and got tapped out twice before reaching the UFC. 

Best Bet | Luana Santos by Decision (-120)

Slight Lean | Luana Santos by Submission (+380)

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Cooper is a Brooklyn-based writer and editor who joined DraftKings in September 2025. A recent graduate of Jay-Z’s Roc Nation School of Sports at Long Island University, he served as the chief sports editor of the campus newspaper and the lead sideline reporter for the men’s basketball team. His previous stops include amNewYork and the New York Post.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.