Monday Night Football Parlay Trends: Washington Commanders vs. San Francisco 49ers 10/19/26

With the 2026 NFL season underway, DraftKings is back with a tool to help you build the ultimate parlay. Start by selecting one pick – an “Anchor” bet – and choose how many legs you want. Then, the Free Trending Parlay Picks Optimizer will give you a custom parlay based on games in which the Anchor bet has previously won.

The Washington Commanders and San Francisco 49ers are set to face off in the final game of Week 6, going head-to-head on Monday Night Football. DraftKings Sportsbook has San Francisco pegged as a 7.5-point favorite at home.

If you feel good about the 49ers winning by more than a touchdown on Monday night, here is a fresh NFL SGP Anchor via the Free Trending Parlay Picks Optimizer.

• San Francisco 49ers -7.5 (-142)
  • Brock Purdy under 21.5 completions (-115)
  • Brock Purdy under 31.5 pass attempts (-113)
  • Christian McCaffrey under 4.5 receptions (+111)
  • George Kittle under 5.5 receptions (-126)

Combined Odds: +700

UPDATE: Jacory Croskey-Merritt (groin) has been placed on Injured Reserve and will not play tonight vs. the 49ers.

Creating a parlay with the appropriate angles on the specific totals listed above would have hit all three times that San Francisco won by more than 7.5 points so far this season. So, instead of simply picking the 49ers to cover at -142, you can ride these additional trends on Monday versus the Commanders.

On the other side of the contest, picking Jacory Croskey-Merritt to rush for over 39.5 yards could be a smart play considering the 49ers have allowed every starting running back they’ve faced this season to clear that mark. The Free Trending Parlay Picks Optimizer has run the numbers on that pick’s past success as an NFL SGP Anchor, as well.

• Jacory Croskey-Merritt over 39.5 rush yards (-110)
  • Jayden Daniels under 18.5 completions (-107)
  • Jayden Daniels under 202.5 passing yards (-112)
  • Over 50.5 total points (-120)

Combined Odds: +750

Creating a parlay with the appropriate angles on the specific totals listed above would have hit all three times that Croskey-Merritt has gone over 39.5 rushing yards this season. Keep these trends in mind if you’re confident in Croskey-Merritt racking up yards Monday night.

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