DKNetwork Logo DKNetwork Logo
Mississippi State Bulldogs vs. Missouri Tigers prediction, pick for College Football on Saturday 9/26/26

Mississippi State Bulldogs vs. Missouri Tigers prediction, pick for College Football on Saturday 9/26/26

Published:

By: Dan Johnson

Bulldogs phenom Kamario Taylor ripped South Carolina for four touchdown passes, hauling Mississippi State out of a 16-0 hole and all the way into a 41-34 win. I’m loving the aggression Jeff Lebby has unleashed, and how niftily it juxtaposes with Taylor’s yes-ma’am kindness with the media. Eli Drinkwitz brings another unbeaten team to Starkville, but Missouri needed its defense and return unit to drag it past Troy just last week. Below is my preview, prediction, and pick for today’s college football game between the Mississippi State Bulldogs and the Missouri Tigers.

Here’s how I’ll play it. I’ll be pumping out these predictions for individual games all season, with plenty of coverage here on DraftKings Network. Follow my handle @dansby_edits for more betting plays.

For easy access to tail my CFB picks swiftly, click here to join the CFB Committee Betting Group on DraftKings Sportsbook.

Mississippi State vs. Missouri prediction, preview

DaMarion Fowlkes bolted 68 yards for a punt-return touchdown against Troy, and they also scored two touchdowns off defensive takeaways. QB Austin Simmons threw for only 91 yards. Ninety-one! Troy hogged possession for 37:23 while the Tigers squeezed in 49 offensive plays. I’ll applaud the return blocking and those takeaways all evening; the offense still has to earn its own first downs.

Jamal Roberts certainly earned his carries, pounding out 128 yards on 22 attempts with Ahmad Hardy still unavailable. Mississippi State presents a nastier appointment: third among 68 Power Four teams in opponent-adjusted rushing defense. Missouri’s offensive line ranks 99th nationally in run push. I expect the Bulldogs to squeeze Roberts’s running lanes and send Simmons into far more demanding passing downs, where he’s not at his best.

State benefited from turnovers in Columbia, too. At Minnesota, however, Lebby’s offense finished its first four possessions with touchdowns and rushed for 252 yards. That’s the sustained scoring I’m buying. Missouri allows only 2.5 yards per carry, so Fluff Bothwell will have to scrap harder here. Taylor’s ability to rescue third-and-long is an absolute keystone to this ticket.

Missouri vs. Mississippi State pick, best bet

Simmons has offensive weapons who can make laying points a frustrating sweat. Cayden Lee and Donovan Olugbode have combined for 515 yards, and State’s adjusted pass defense ranks a weak 47th/68th. I see Missouri at 24 points. Let those two rip off some catches, and let the good times roll. My larger concern is whether Roberts can keep his offense from hiccuping between passing downs and punts.

I’m laying 5.5 at -110, projecting Mississippi State 34-24. I’m backing Taylor to finish more drives. His spectacular touchdown to Marquis Johnson at South Carolina came after he evaded pressure on third-and-long. He just looks too good right now.

Best bet: Mississippi State -5.5 (-110)

Projected score: Mississippi State 34, Missouri 24

Best Bet: Mississippi State -5.5 (-110) at Missouri

For easy access to tail my CFB picks swiftly, click here to join the CFB Committee Betting Group on DraftKings Sportsbook.

Dan Johnson has been an editor, writer, and analyst for DraftKings and DraftKings Network since 2024. He’s previously held editorial posts at The Paris Review, Macmillan Publishers, Bedford/St. Martin’s Press, ASSIGNMENT Magazine, and FantasySixPack. You can find his various editorial work & writing (sports-related and non-) at all of the above.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user (my username is thegreatdansby9) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.