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Opening odds and spread for Cardinals vs Chargers in NFL Week 1

Opening odds and spread for Cardinals vs Chargers in NFL Week 1

Los Angeles Chargers Sports Betting Picks NFL NFL Betting

Published:

By: Ciaran Doyle

The opening odds for the Arizona Cardinals vs. Los Angeles Chargers Week 1 matchup on Sunday are now available on DraftKings Sportsbook.

Cardinals vs. Chargers Opening Odds

The Chargers open as 11.5-point favorites for this game. They are -625 favorites on the moneyline, while the Cardinals are +455 on the moneyline. The O/U is listed at 45.5 points.

These teams haven’t matched up since 2024 with the Cardinals getting a 17-15 victory. The Chargers are coming off an 11-6 season where they fell to the Patriots in the playoffs. The Cardinals had a season to forget with a 3-14 record.

L.A. are huge favorites in Week 1 to get their 2026 season started.

Ciaran Doyle
Ciaran has been an editor for the DraftKings Network team since 2023. He graduated from the University of Arizona before attending Arizona State University for his master’s degree in sports journalism. Ciaran previously covered Phoenix Rising FC for Cronkite News before joining DraftKings. He is passionate about sports betting, and his biggest focus has always been on the NFL and soccer. You can find him on X at @Ciaran_Doyle7.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user (my username is ciarandoyle77) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.