Looking for the best MLB picks today? DraftKings Network analysts share their top bets and predictions for Wednesday’s slate on DraftKings Sportsbook.
To see all DraftKings betting analysis, head over to the DraftKings Network sports betting picks page!
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Garion Thorne: Top Home Run Props
Picks below! Read Garion’s full betting analysis here: MLB Best Bets: Top Home Run Props for Wednesday 4/1/26
Spencer Torkelson 1+ Home Run (+460)
Byron Buxton 1+ Home Run (+294)
Dan Johnson: Astros vs. Red Sox prediction, pick
Pick below! Read Dan’s full betting analysis here: Houston Astros vs. Boston Red Sox prediction, pick for MLB on Wednesday 4/01/26
Red Sox -1.5 (+120) at Astros
Charlie Cummings: White Sox vs. Marlins prediction, pick
Pick below! Read Charlie’s full betting analysis here: Chicago White Sox vs. Miami Marlins prediction, pick for Wednesday 4/1/26
Miami Marlins Run Line -1.5 (+141)
Brendan O’Sullivan: Mets vs. Cardinals prediction, pick
Pick below! Read Brendan’s full betting analysis here: New York Mets vs. St. Louis Cardinals prediction, pick for MLB on Wednesday 4/1/26