DKNetwork Logo DKNetwork Logo
NFL Betting Cheat Sheet: Best Bets, Picks, Props for Week 16 on Sunday 12/21/25

NFL Betting Cheat Sheet: Best Bets, Picks, Props for Week 16 on Sunday 12/21/25

Buffalo Bills Sports Betting Picks NFL DraftKings Sportsbook Insights Rail

Updated:

By: DK.Network.Editors

Every week, DraftKings Network analysts share their favorite NFL bets on DraftKings Sportsbook for each NFL game.

Below is a collection of the top NFL best bets for the Week 16 NFL Sunday slate.

NFL Betting Cheat Sheet: Best Bets, Picks, Props for Week 16 on Sunday 12\/21\/25","category":"sports-betting-picks,nfl,draftkings-sportsbook-insights","post_tag":"rail"}" style="--dkn-ad-h-1024: 90px;--dkn-ad-h-768: 90px;--dkn-ad-h-375: 50px;">

RELATED Week 16 NFL Injury Report for Sunday 12/21/25

To see all DraftKings betting analysis, head over to the DraftKings Network sports betting picks page!

Check out the numerous NFL betting markets available on DraftKings Sportsbook!

Dan Johnson: Denver Broncos vs. Jacksonville Jaguars prediction, pick

Picks below! Read Dan’s full betting analysis here: Denver Broncos vs. Jacksonville Jaguars prediction, pick for NFL Week 16 on Sunday 12/21/25

Jaguars +3.5 (-120) at Broncos

Jakobi Meyers 60+ receiving yards (+115)

Charlie Cummings: Buffalo Bills vs. Cleveland Browns prediction, pick

Picks below! Read Charlie’s full betting analysis here: Buffalo Bills vs. Cleveland Browns prediction, pick for NFL Week 16 on Sunday 12/21/25

Under 41.5 Total Points (-112)

Blake Krass: Best NFL Week 16 Player Prop Bets

Picks below! Read Blake’s full betting analysis here: Best NFL Week 16 Player Prop Bets for Sunday 12/21/25

Quinshon Judkins Anytime TD (+105)

Oronde Gadsden II o39.5 Receiving Yards (-109)

Rico Dowdle 15+ Receiving Yards (-114)

DK.Network.Editors
Disclaimer

DraftKings promoters may sometimes play on personal accounts in the games that advice is offered on. Personal views on the games and strategies above do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. DraftKings promoters may also deploy different players and strategies than what is recommended above. DraftKings promoters do not have access to any non-public information.