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Kentucky Wildcats vs. Louisville Cardinals prediction, pick for CFB Week 14 on Saturday 11/29/25

Kentucky Wildcats vs. Louisville Cardinals prediction, pick for CFB Week 14 on Saturday 11/29/25

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By: Julian Edlow

Kentucky vs. Louisville prediction, preview

Backing Kentucky on the road isn’t exactly the most comfortable bet (1-3 SU/ATS this season), but the Wildcats look to be in a strong spot to wrap up their year. Prior to last week’s loss to Vandy, Kentucky was on a three-game winning streak, with outright wins as an underdog over Florida and Auburn. After battling the tough schedule of the SEC all season, the Wildcats should come ready to prove themselves for a big in-state rivalry game.

While Louisville has found ways to win on the road this season, it hasn’t exactly been tough to go up against at home. The Cardinals are just 4-3 straight up at home, and haven’t covered a single home game this season (0-7 ATS – failing to cover by 7.6 PPG)! Miller Moss is considered unlikely to play after missing last week’s blowout loss at SMU, and Louisville has made mention to using multiple quarterbacks in this game. That didn’t go well last week. I think that’s an advantage for this Kentucky defense.

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The Wildcats are 5-1 SU/ATS in the last six meetings with Louisville, and I expect them to continue that trend. Look for Kentucky to be led by its defense, and capable of enough offensively to get the outright win.

CFB Pick: Kentucky +3.5 (-110)

Find my full CFB Week 14 betting card right here on DraftKings Network!

Julian Edlow has contributed to DraftKings since 2015, and is currently employed as a Content Specialist with a focus on Sports Betting. During his time at DK, Julian has experience covering the NFL, NBA, MLB, College Football and College Basketball. He has also has experience covering both Daily Fantasy Sports and Sportsbook as a writer and on-air talent. Prior to arriving at DK, Julian was a reporter covering the Boston Celtics and the NBA for multiple outlets. Julian is currently leading the charge on DK Network’s College Football and College Basketball coverage, although you’ll still find him contributing to NFL and NBA.
Disclaimer

All views expressed are my own. I am an employee of DraftKings and am ineligible to play in public DFS or DKSB contests.