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MLB Best Bets: Top MLB predictions and picks for Monday 8/18/25

MLB Best Bets: Top MLB predictions and picks for Monday 8/18/25

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By: Dan Johnson

Let’s get some new series underway as the autumnal air visits August, shall we? I’ve already got write-ups for Red Sox vs. Orioles, Phillies vs. Mariners, and Marlins vs. Cardinals games up for your viewing pleasure. Erstwhile, based on my preliminary research, here are my three favorite baseball bets for tonight’s slate, separate from my game predictions and previews.

Links to DraftKings Sportsbook provided for all bets below!


Marlins (-145) vs. Cardinals

I’m leaning Marlins moneyline behind a tangible mound edge and a friendlier game script in Miami. The number is generally in the -135 to -144 pocket, which prices Eury Pérez’s superiority but still leaves meat on the bone given St. Louis’ current state. Pérez brings a 3.58 ERA, a microscopic 0.98 WHIP, and a strikeout rate north of 25% into a park that tamps down loft. He’s been nastier at home, logging a 2.08 ERA across four starts, and his traffic suppression neutralizes crooked innings. Matthew Liberatore’s headline numbers are respectable, yet the profile leans contact: 17.6% K rate, 5.6% walks, and a homer rate under one per nine that is partially protected by context. He’s steadier on the road with a 3.59 ERA, but that comes with low swing-and-miss, which hands leverage to a Marlins offense that manufactures runs with ball-in-play pressure.

Macro angles align. Miami is 15-4 to the under at home against low-slug NL lineups, underscoring how their pitching and park collaborate to control games when the opponent lacks thump. St. Louis qualifies on that front, and the Cardinals also trend 12-4 to the under on the road versus sub-1.25 WHIP NL starters, a trend that ties directly to Pérez’s efficiency. Head-to-head context favors Miami recently, with four wins in the last five meetings and an earlier series win in St. Louis. The Cardinals enter on a five-game skid and carry notable lineup uncertainty, which further narrows their margin for error on the road. I respect Liberatore’s improved road ERA, but the matchup penalizes soft contact, and Miami’s bullpen has covered these scripts well when handed a lead. With the better starter, the friendlier environment, and supportive trends, I’ll lay the price.

Orioles (+100) at Red Sox

I’m backing Baltimore moneyline at even to small plus prices, anchored by a decisive starting-pitching edge. Trevor Rogers has been a revelation: 1.43 ERA, 0.81 WHIP, deep outings, microscopic contact quality, and only two homers allowed in 69 innings. His profile fits Fenway because he lives below barrels and limits fly-ball damage, which blunts the Monster’s usual tax. Dustin May counters with a 4.67 ERA and 1.35 WHIP, flashing strikeouts but leaking slug, particularly to left-handed bats. Baltimore’s order can stack lefties and switch hitters to pressure that split from pitch one.

Recent form supports the play. Baltimore has won four of five and just detonated Houston 12–0 behind a four-hit Jordan Westburg showcase, signaling healthier swing decisions up and down the card. The Orioles also took the last two meetings versus Boston, trimming the H2H deficit while proving they can travel. Boston remains formidable at Fenway and just took two of three from Miami, but May’s inconsistency reintroduces midgame volatility that Rogers largely avoids. The weather lean is modestly hitter-friendly with a light breeze out, yet Rogers’ barrel and ground-ball rates historically suppress wind-aided carry, while May’s split-driven homer issues remain in play.

Market context cooperates. Openers around BOS -120 drifted into a two-way pocket, and the total’s under juice reflected respect for Rogers’ run prevention. That pull increases the value of the true difference-maker: the starter gap. Baltimore’s bullpen has been stretched by injuries, but Rogers’ length has insulated leverage usage; a standard seven-inning path leaves only two clean frames for setup/closer types. Boston’s pen just showed cracks late, which matters in one-score scripts. I’ll take elite contact management, a cleaner walk profile, and better HR suppression at plus money.

Phillies vs. Mariners o8.0 total runs (+100)

Citizens Bank Park rewards lifted contact and punishes mistakes to the gaps and pull-side seats, which pushes totals toward the upper end when either starter scatters command. Philadelphia’s lineup carries real game-to-game homer equity at home, and Seattle brings enough torque to cash their share of extra-base hits even in lower-hit games. That combination matters with an eight posted, where one crooked inning often flips the math.

From a pitching-shape angle, this sets up as a “both teams score” profile rather than a one-sided blowout. Philadelphia’s starter form has flickered of late with more traffic and fewer chases, which elevates pitch counts and introduces midgame leverage earlier than ideal. Seattle’s probable front man is high quality, yet even strong right-handers don’t skate clean in this yard when facing a Phillies core that punishes four-seam leaks and ambushes early-count mistakes. The practical effect is a totals posture where seven looks reachable through seven innings without requiring sequence perfection or bullpen meltdowns.

Relief units tilt the last third toward runs as well. Philadelphia’s late-game group is dangerous but volatile when entering with inherited runners, and Seattle’s path from seventh to ninth can trade whiffs for occasional loud contact. In an eight-run market, those slim cracks matter. I also like how both offenses manufacture secondary scoring beyond the long ball: sac flies, opposite-field liners, and hustle doubles sustain innings even when swings miss the barrel by a hair.

I don’t need shootout chaos; I need steady pressure and one three-run frame. The environment, matchup dynamics, and lineup power sources collectively clear that bar often enough to justify a position. If you want insulation, split stake Over 8 and live over 6.5 on a scoreless first.

Dan Johnson has been an editor, writer, and analyst for DraftKings and DraftKings Network since 2024. He’s previously held editorial posts at The Paris Review, Macmillan Publishers, Bedford/St. Martin’s Press, ASSIGNMENT Magazine, and FantasySixPack. You can find his various editorial work & writing (sports-related and non-) at all of the above.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user (my username is thegreatdansby9) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.