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Real Madrid vs. RB Leipzig prediction, pick for Wednesday 10/21/26

Real Madrid vs. RB Leipzig prediction, pick for Wednesday 10/21/26

Published:

By: Ciaran Doyle

The 2026/27 UCL league phase continues on Wednesday as Real Madrid host RB Leipzig.

Madrid are -400 favorites on DraftKings Sportsbook for this one, with a draw available at +600. Fancy a RB Leipzig upset? The German side is +850 on the moneyline.

Real Madrid vs. RB Leipzig Prediction, Pick

This bet can be found under the “Match Parlays” tab. Real Madrid are the better team here, and I think they will get the win and four or more goals will be scored in this match. Madrid have won each of their first two UCL games, with four or more goals being scored on one occasion. First they took down Inter Milan 2-1, and then they had a come-from-behind win against Roma to steal the three points in a 4-3 contest. Now they will look to make it three from three, and standing in their way is RB Leipzig.

Leipzig are not off to a great start in either the Bundesliga or UCL so far this season. In the league, they are in seventh place, winning three and losing three of their opening six games. In the Champions League, their record is also .500, winning one and losing one of their first two league phase matches. They suffered a 4-1 defeat away to Como in the opening match before beating PSV 1-0 at home. All three of their league wins came at home, as well as their UCL win. Away from home, they have lost all four matches in both competitions while being outscored 15-3.

Real Madrid will be licking their chops at those statistics. Madrid have been perfect at home, winning all five of their La Liga matches and their sole UCL game at the Bernabéu. In those six combined games they have outscored their opponents by a total of 19-4. This feels like a great matchup for Real Madrid to get the win and score plenty of goals in the process.

The Pick: Real Madrid Win and Over 3.5 (-120)

Ciaran has been an editor for the DraftKings Network team since 2023. He graduated from the University of Arizona before attending Arizona State University for his master’s degree in sports journalism. Ciaran previously covered Phoenix Rising FC for Cronkite News before joining DraftKings. He is passionate about sports betting, and his biggest focus has always been on the NFL and soccer. You can find him on X at @Ciaran_Doyle7.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user (my username is ciarandoyle77) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.