Sunday afternoon’s loaded NFL Week 4 slate features an AFC East showdown between the New England Patriots and the Buffalo Bills at Highmark Stadium, with kickoff set for 1 p.m. ET.
The Patriots (1–2, 2nd AFC East) will attempt to rebound from a brutal 35–6 walloping in Jacksonville against the Jaguars. The Bills (3–0, 1st AFC East) are looking to preserve their perfect record following last week’s 24–16 home win over the Los Angeles Chargers.
The Bills enter as seven-point home favorites with -305 moneyline odds on DraftKings Sportsbook. The Patriots are +245 underdogs, with the game total set at O/U 49.5 points.
Let’s dive into the top player prop bets for Sunday’s clash between the Patriots and the Bills.
Patriots vs. Bills NFL Player Prop Bets for Week 4
Drake Maye 1+ Interceptions Thrown (-129)
Following a breakout campaign in 2025, Drake Maye hasn’t just come down to earth — he’s plunged to new depths. In a jarring regression, last year’s MVP runner-up has looked unrecognizable through the first three weeks. Maye, 24, has completed only 63.7 percent of his passes for 585 yards and just one touchdown, versus an NFL-high six interceptions.
The Patriots and their beleaguered quarterback will likely have to keep putting the ball in the air in Sunday’s matchup against the Bills — armed with the sport’s most potent offense. Maye has thrown at least one interception in each of New England’s games this season — highlighted by three picks in Week 1 — and should serve up another meatball sub in Buffalo.
DJ Moore 60+ Receiving Yards (+137)
DJ Moore bounced back nicely from his Week 2 injury, hauling in six of 10 targets for 67 yards in last Sunday’s win over the Chargers. Buffalo’s new top receiver has cleared 60 receiving yards in two games so far, highlighted by a 100-yard outburst with a touchdown in the team’s season opener.
Moore, 29, has a clear runway to follow suit against a depleted Patriots defense missing several key contributors — including star cornerback Christian Gonzalez (shoulder). With the best quarterback in football throwing him the ball, there’s solid value in backing Moore to crush this plus-odds prop for the third time this year.
