DKNetwork Logo DKNetwork Logo
Best MLB Parlays Today: Top Picks for Wednesday, September 16

Best MLB Parlays Today: Top Picks for Wednesday, September 16

Published:

By: Steve Buchanan

Looking for today’s best MLB parlays? We’ve highlighted several featured parlays available on DraftKings Sportsbook, including home run parlays, NRFI parlays, total bases parlays, hits + runs + RBIs parlays, strikeout parlays, moneyline parlays and MLB game total parlays built around Wednesday’s MLB slate.

Below, you’ll find today’s featured MLB parlays along with a breakdown of what’s included before adding each one to your bet slip on DraftKings Sportsbook. Whether you’re looking for home run picks, NRFI picks, player props, strikeout parlays, moneyline parlays or game totals, today’s featured bets cover a wide range of MLB markets.

Home Run Parlay: Big Bats

The Big Bats home run parlay on DraftKings Sportsbook backs Junior Caminero and Pete Alonso to go deep on Wednesday’s MLB slate. Both sluggers rank among the top nine in home runs this season and need to record at least one home run to cash this two-leg home run parlay.

  • Junior Caminero 1+ Home Run
  • Pete Alonso 1+ Home Run
Parlay

Big Bats

These sluggers rank Top 9 in HRs this season | Back them to go yard!

Odds: +1408

Junior Caminero 1+ Home Run Junior Caminero Home Runs
Pete Alonso 1+ Home Run Pete Alonso Home Runs
Ends in: --:--
+ Add to Bet Slip

Home Run Parlay: Star Sluggers

The Star Sluggers home run parlay on DraftKings Sportsbook backs Ben Rice and Pete Alonso to go deep on Wednesday’s MLB slate. Rice enters the day with 38 home runs this season, tied for fifth in MLB, while Alonso ranks ninth with 36. Both hitters need to record at least one home run to cash this two-leg home run parlay.

  • Ben Rice 1+ Home Run
  • Pete Alonso 1+ Home Run
Parlay

Star Sluggers⭐

HRs this season: Rice 38 (T-5th) | Alonso 36 (9th)

Odds: +1671

Ben Rice 1+ Home Run Ben Rice Home Runs
Pete Alonso 1+ Home Run Pete Alonso Home Runs
Ends in: --:--
Bet Count: 260
+ Add to Bet Slip

NRFI Parlay: First Inning Freeze

The First Inning Freeze NRFI parlay on DraftKings Sportsbook backs four matchups to remain scoreless through the first inning on Wednesday’s MLB slate. The Dodgers-Reds, Brewers-Pirates, Athletics-Rays and Phillies-Nationals games each need a scoreless opening frame to cash this four-leg NRFI parlay.

  • Los Angeles Dodgers at Cincinnati Reds – No Runs 1st Inning
  • Milwaukee Brewers at Pittsburgh Pirates – No Runs 1st Inning
  • Athletics at Tampa Bay Rays – No Runs 1st Inning
  • Philadelphia Phillies at Washington Nationals – No Runs 1st Inning
Parlay

First Inning Freeze🥶

Back these pitchers to throw a shutout in the 1st inning on Wednesday!

Odds: +859

LAD @ CIN: No Runs 1st Inning Runs - 1st Inning (Under)
MIL @ PIT: No Runs 1st Inning Runs - 1st Inning (Under)
ATH @ TB: No Runs 1st Inning Runs - 1st Inning (Under)
PHI @ WAS: No Runs 1st Inning Runs - 1st Inning (Under)
Ends in: --:--
+ Add to Bet Slip

NRFI Parlay: Donut Delivery

The Donut Delivery NRFI parlay on DraftKings Sportsbook backs four matchups to remain scoreless through the first inning on Wednesday’s MLB slate. The White Sox-Guardians, Giants-Cardinals, Yankees-Twins and Tigers-Blue Jays games each need a scoreless opening frame to cash this four-leg NRFI parlay.

  • Chicago White Sox at Cleveland Guardians – No Runs 1st Inning
  • San Francisco Giants at St. Louis Cardinals – No Runs 1st Inning
  • New York Yankees at Minnesota Twins – No Runs 1st Inning
  • Detroit Tigers at Toronto Blue Jays – No Runs 1st Inning
Parlay

Donut Delivery🍩

Wager on these matchups to have zero runs scored in the 1st inning!

Odds: +954

CWS @ CLE: No Runs 1st Inning Runs - 1st Inning (Under)
SF @ STL: No Runs 1st Inning Runs - 1st Inning (Under)
NYY @ MIN: No Runs 1st Inning Runs - 1st Inning (Under)
DET @ TOR: No Runs 1st Inning Runs - 1st Inning (Under)
Ends in: --:--
Bet Count: 621
+ Add to Bet Slip

Total Bases Parlay: Two-Bag Business

The Two-Bag Business total bases parlay on DraftKings Sportsbook backs three hitters to record at least two total bases on Wednesday’s MLB slate. Aaron Judge, Shea Langeliers and Pete Alonso each need to reach the 2+ total bases mark to cash this three-leg player prop parlay.

  • Aaron Judge 2+ Total Bases
  • Shea Langeliers 2+ Total Bases
  • Pete Alonso 2+ Total Bases
Parlay

Two-Bag Business

Three big bats, back Judge, Langeliers and Alonso to each rack up 2+ total bases

Odds: +926

Aaron Judge 2+ Total Bases Aaron Judge Total Bases
Shea Langeliers 2+ Total Bases Shea Langeliers Total Bases
Pete Alonso 2+ Total Bases Pete Alonso Total Bases
Ends in: --:--
+ Add to Bet Slip

Strikeout Parlay: High Five

The High Five strikeout parlay on DraftKings Sportsbook backs four pitchers to record at least five strikeouts on Wednesday’s MLB slate. Nick Martinez, Zack Wheeler, Robert Stock and Chris Bassitt each need to reach the 5+ strikeout mark to cash this four-leg pitching parlay.

  • Nick Martinez 5+ Strikeouts
  • Zack Wheeler 5+ Strikeouts
  • Robert Stock 5+ Strikeouts
  • Chris Bassitt 5+ Strikeouts
SGPx

High Five✋

Back these pitchers to throw heat & tally 5+ strikeouts!

Odds: +1052

Nick Martinez 5+ Strikeouts Nick Martinez Strikeouts Thrown
Zack Wheeler 5+ Strikeouts Zack Wheeler Strikeouts Thrown
Robert Stock 5+ Strikeouts Robert Stock Strikeouts Thrown
Chris Bassitt 5+ Strikeouts Chris Bassitt Strikeouts Thrown
Ends in: --:--

Strikeout Parlay: K Crew

The K Crew strikeout parlay on DraftKings Sportsbook backs three pitchers to reach their respective strikeout marks on Wednesday’s MLB slate. Carlos Rodon and Robert Stock each need 6+ strikeouts, while Nick Martinez needs 5+ to cash this three-leg pitching parlay.

  • Carlos Rodon 6+ Strikeouts
  • Robert Stock 6+ Strikeouts
  • Nick Martinez 5+ Strikeouts
Parlay

K Crew

Back the K Crew to command the zone, miss bats and pile up the strikeouts

Odds: +1264

Carlos Rodon 6+ Strikeouts Carlos Rodon Strikeouts Thrown
Robert Stock 6+ Strikeouts Robert Stock Strikeouts Thrown
Nick Martinez 5+ Strikeouts Nick Martinez Strikeouts Thrown
Ends in: --:--
Bet Count: 109
+ Add to Bet Slip

Hits + Runs + RBIs Parlay: Triple Threat

The Triple Threat hits + runs + RBIs parlay on DraftKings Sportsbook backs three hitters to contribute across the box score on Wednesday’s MLB slate. Junior Caminero, Kyle Schwarber and Juan Soto each need at least three combined hits, runs and RBIs to cash this three-leg player prop parlay.

  • Junior Caminero 3+ Hits + Runs + RBIs
  • Kyle Schwarber 3+ Hits + Runs + RBIs
  • Juan Soto 3+ Hits + Runs + RBIs
Parlay

Triple Threat

Back these superstars to fill up the stat-sheet in Wednesday's action!

Odds: +1038

J. Caminero 3+ Hits + Runs + RBIs Junior Caminero Hits + Runs + RBIs
K. Schwarber 3+ Hits + Runs + RBIs Kyle Schwarber Hits + Runs + RBIs
J. Soto 3+ Hits + Runs + RBIs Juan Soto Hits + Runs + RBIs
Ends in: --:--
+ Add to Bet Slip

Moneyline Parlay: Favorites Flex

The Favorites Flex moneyline parlay on DraftKings Sportsbook backs five teams to earn victories on Wednesday’s MLB slate. The Blue Jays, Mets, Cubs and Astros are backed to win at home, while the Yankees need to pick up a road win over the Twins to cash this five-leg moneyline parlay.

  • New York Yankees Moneyline at Minnesota Twins
  • Toronto Blue Jays Moneyline vs. Detroit Tigers
  • New York Mets Moneyline vs. Baltimore Orioles
  • Chicago Cubs Moneyline vs. Atlanta Braves
  • Houston Astros Moneyline vs. Kansas City Royals
Parlay

Favorites Flex💪

Bet these favorites to handle business in Wednesday's action!

Odds: +1341

NY Yankees to Win (@ MIN) Moneyline (Away)
TOR Blue Jays to Win (vs DET) Moneyline (Home)
NY Mets to Win (vs BAL) Moneyline (Home)
CHI Cubs to Win (vs ATL) Moneyline (Home)
HOU Astros to Win (vs KC) Moneyline (Home)
Ends in: --:--
Bet Count: 504
+ Add to Bet Slip

MLB Over Parlay: Bats Are Hot

The Bats Are Hot MLB totals parlay on DraftKings Sportsbook backs four matchups to finish over their listed run totals on Wednesday’s MLB slate. The Red Sox-Rangers, Royals-Astros, Padres-Rockies and Mariners-Angels games all need to clear their respective totals to cash this four-leg Over parlay.

  • Boston Red Sox at Texas Rangers – Over 8 Runs
  • Kansas City Royals at Houston Astros – Over 9 Runs
  • San Diego Padres at Colorado Rockies – Over 11.5 Runs
  • Seattle Mariners at Los Angeles Angels – Over 8 Runs
Parlay

Bats Are Hot

Take these offenses to be hot & hit the over in Wednesday!

Odds: +1194

BOS @ TEX: Over 8 Runs Total (Over)
KC @ HOU: Over 9 Runs Total (Over)
SD @ COL: Over 11 Runs Total (Over)
SEA @ LAA: Over 8 Runs Total (Over)
Ends in: --:--
+ Add to Bet Slip

Whether you’re targeting home runs, NRFI markets, total bases, hits + runs + RBIs, strikeouts, moneylines or game totals, DraftKings Sportsbook offers a variety of MLB parlay options throughout Wednesday’s schedule.

MLB Parlays FAQ

What is an MLB parlay?

An MLB parlay combines multiple betting selections into a single wager. Every leg of the parlay must win for the bet to cash, but successful parlays offer larger potential payouts than betting each selection individually.

Can I bet same-game parlays on DraftKings Sportsbook?

Yes. DraftKings Sportsbook offers same-game parlays featuring player props, moneylines, run lines, totals, home run props, strikeout props, NRFI markets and other MLB betting options. Available markets may vary by game and jurisdiction.

Featured MLB parlays may include home run parlays, NRFI parlays, total bases parlays, hits + runs + RBIs parlays, strikeout parlays, moneyline parlays, MLB totals parlays and other player prop combinations depending on the day’s MLB schedule.

All views expressed are my own. I am an employee of DraftKings and am ineligible to play in public DFS or DKSB contests.