Heading into the home stretch of the 2025 NFL season, DraftKings has launched a brand new tool to help you build the ultimate parlay. Start by selecting one pick – an “Anchor” bet – and choose how many legs you want. Then, the Free Trending Parlay Picks Optimizer will give you a custom parlay based on games in which the Anchor bet has previously won.
The San Francisco 49ers and Indianapolis Colts are set to face off on Monday Night Football in Week 16 with major playoff implications on the line. The 49ers are still in the running for the NFC West title and a first-round bye, but their margin for error is razor-thin. The stakes are even higher for the Colts, who would be on the brink of elimination with a loss. It has been quite the fall from grace for Indianapolis, all while 44-year-old Philip Rivers tries to break up their 1-5 skid. DraftKings Sportsbook has San Francisco pegged as a 5.5-point favorite.
If you feel good about the 49ers holding off the Colts, here is a fresh NFL SGP Anchor via the Free Trending Parlay Picks Optimizer.
- San Francisco 49ers Moneyline (-258)
- San Francisco 49ers First Team to Score (-110)
- Brock Purdy under 33.5 pass attempts (-114)
- Christian McCaffrey anytime TD (-215)
- George Kittle over 60+ alt receiving yards (-161)
- Jauan Jennings under 54.5 receiving yards (-111)
- Kendrick Bourne under 2.5 receptions (-183)
- Kendrick Bourne under 22.5 receiving yards (-108)
Combined Odds: +2500
Creating a parlay with the appropriate angles on the specific totals listed above would have hit in each of San Francisco’s last four wins. So, instead of simply picking 49ers moneyline at -258, you can ride these additional trends on on Monday vs. the Colts.
If you are all-in on the Colts pulling off the upset and staying alive, the Free Trending Parlay Picks Optimizer has run the numbers on that pick’s past success as an NFL SGP Anchor, as well.
- Indianapolis Colts Moneyline (+210)
- Indianapolis Colts First Team to Score (-120)
- Jonathan Taylor Anytime Touchdown (-240)
- Jonathan Taylor 90+ alt rushing yards (-158)
- Alec Pierce over 1.5 receptions (-144)
- Alec Pierce 40+ alt receiving yards (+260)
- Tyler Warren over 3.5 receptions (-153)
- Tyler Warren 50+ alt receiving yards (+192)
Combined Odds: +7500
Creating a parlay with the appropriate angles on the specific totals listed above would have hit the last four times the Colts won. Keep these trends in mind if you’re confident in Indianapolis getting back on track Monday night.
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