Week 7 of the 2025 NFL season continues with a great Monday Night Football doubleheader. The night starts with a battle between the Buccaneers and Lions, followed by a late-night game between the Texans and Seahawks. There are far more ways to get involved in the action than just via traditional betting. One of the more unique features on DraftKings this season is Pick6 Fantasy Football!
Here are my top Pick6 plays for Week 7 Monday Night Football.
Nico Collins More than 0.5 Rush + Receiving Touchdowns
After a slow Week 1, Nico Collins has been rolling the past four games. He is averaging 7.8 catches for 71.8 yards over the past four games. Over that stretch, he has three receiving touchdowns as well. This game against Seattle is a great chance for Collins to get another touchdown on the board. The way to attack the Seahawks’ defense is through the air. The defense has been tough all season, but they are nearly impossible to run against. Seattle ranks third in the NFL in defensive EPA/rush but 16th in defensive EPA/dropback. Nico Collins is getting 35.3% of the red-zone targets for the Texans this season as C.J. Stroud continues to look his way. That gives Collins a great chance to add another touchdown to his season total.
Baker Mayfield More Than 0.5 Interceptions Thrown
It has been an MVP-level season so far for Baker Mayfield in 2025. Mayfield has been carrying this Tampa Bay team on his back. The Buccaneers have been poor defensively and have dealt with a plethora of offensive injuries. Unfortunately for Mayfield, those injuries keep stacking up, and he could finally have a down game against the Lions. There is a chance Mayfield will be without Mike Evans, Emeka Egbuka, Chris Godwin and Jalen McMillan in this game, Tampa Bay’s top four receivers coming into this season. The Lions have an incredible offense and are likely to score a lot of points against Tampa Bay. That means Mayfield will need to be aggressive through the air while potentially throwing to some unfamiliar targets. That should lead to an interception for Mayfield, something he has struggled with throughout his career.
Woody Marks More Than 46.5 Rushing + Receiving Yards
Woody Marks is one of the under-the-radar rookies having a promising start to the season. Marks was a dynamic playmaker at USC but was not expected to have a big role in this offense this season. The Texans returned Joe Mixon at running back and added Nick Chubb as a veteran backup. That would have left limited snaps for Marks, but an injury to Mixon opened the door for the rookie. Chubb is getting a majority of the carries, but he does not have the speed and burst that Marks has. Marks has been the change-of-pace back and the receiving threat out of the backfield. He had a breakout game two weeks ago against Tennessee, combining for 119 scrimmage yards. Against a tough Seattle defense, Marks is the type of player who could break things open for Houston and create a big play. Marks has the potential to get over this number on just one broken play, but should get enough touches to get over this number regardless.
What is DraftKings Pick6?
Pick6 is a peer-to-peer fantasy variant where you build a lineup (your “Pick Set”) of 2+ players and select whether you believe each will outperform their listed stat projection. Enter your Pick Set in Pick6 contests to compete against other users. Get enough picks correct and win a share of cash prizes.
How to Play
Create a Pick Set
Create a Pick Set by choosing 2+ players from the same sport and Pick Group (a set of picks available from a group of set competitions). For each player, simply select if you think they’ll have more or less than their listed stat projection. In each Pick Set, you can not pick the same player twice, and you must pick players from at least two different teams.
Enter an Amount
Once you finalize your Pick Set, choose your entry fee amount. Your entries will be automatically distributed into available contests, subject to your confirmation.
Sweat Your Picks
When the games go live, use the My Picks tab to follow your picks in real time to track how your players are performing against their projections and how they stack up against other users.
Compete for Prizes
Make enough correct picks and win a share of the contests’ guaranteed prizes. Any prizes won will be credited to your DraftKings account after contests are finalized.
Play at DraftKings Pick6 or by downloading the DraftKings Pick6 app on Apple or Google!
