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Patrick Mahomes best prop bets for Chiefs vs. Lions on Sunday 10/12/25

Patrick Mahomes best prop bets for Chiefs vs. Lions on Sunday 10/12/25

Sports Betting Picks NFL DraftKings Sportsbook Insights

Published:

By: Alex Hunter

The Chiefs are hosting the Lions on Sunday night. On DraftKings Sportsbook, Kansas City is favored by 2.5 points, and this game carries a total of O/U 52.5 points.

Below, I have featured my favorite Patrick Mahomes prop to consider from this contest.

Best Patrick Mahomes Prop Bets on DraftKings Sportsbook

Patrick Mahomes 25+ Rushing Yards (-122)

Mahomes has been excellent with his legs this season, ranking fourth among quarterbacks in rushing yards (190), including at least 57 rushing yards in three of his five starts. Among the quarterbacks that have seen at least 10 carries this season, Mahomes ranks second in yards per carry (6.8), second in yards after contact (149) and fourth in missed tackles forced (4).

The three-time Super Bowl champion is averaging 5.6 carries per game, and the Chiefs are scrambling at the third-highest rate in the league (10.4%). Up next for Mahomes is a matchup with a Lions defense that is pressuring quarterbacks at the fourth-highest rate this season (41.3%).

The heavy pressure from Detroit should force Mahomes to rush often, giving the quarterback a terrific chance to rush for at least 25 yards in this likely shootout. Notably, this contest’s 52.5-point total on DraftKings Sportsbook is the highest total the NFL has seen this season.

Alex Hunter
Alex Hunter is an avid DFS player and sports handicapper, who has been a proud member of the DraftKings Network team since 2020. He is a data-driven analyst, who earned his bachelor’s degree in communications at Worcester State University and has been in the sports content business for nearly a decade, covering the NBA, NFL and PGA TOUR. Alex is a diehard Boston Celtics fan, who loves to be on the golf course when he isn’t grinding lineups or producing content. For all of Alex’s work or if you need any lineup advice, be sure to follow him @Hunta512 on X.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user (my username is Hunta512) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.