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NFL Pick ‘Em Pool Predictions for Week 6 2025

NFL Pick ‘Em Pool Predictions for Week 6 2025

Updated:

By: Blake Krass

There are so many different ways to make your picks for Week 6 of the NFL season on DraftKings and DraftKings Sportsbook. The DraftKings Pick ‘Em Pools are one of the best ways to get in on the action.

DraftKings has huge NFL Pick ‘Em Pools for Week 6. You can enter the $5 NFL Week 6 Spreads Pool with $5,000+ in prizes here. You can also enter the $100 NFL Week 6 Spreads Pool with $4,000+ in prizes here.


NFL Pick ‘Em Pools

These pools are really easy to use and allow you to have action for the entire NFL season with just one entry fee. For the season-long pools, each week you will go back to the pool and pick five games on the slate against the spread. Each correct selection is worth one point. You will also be given one “skip week” during the season, where you don’t need to make picks if you don’t have a good feel for that slate. That way, even if you have one bad week, you are still in contention in the contest. You can also play the weekly pools, where you pick every featured game against the spread.

Every week of the regular season, I will be giving out my five favorite selections, along with my leans for every other game on the slate.

Week 6 Picks

Falcons +4.5 vs. Bills — This is a prime spot for the Falcons to catch the Bills. Buffalo is coming off an emotional primetime loss against their division rivals. New England showed how you can attack this Buffalo defense and have some success. The Bills rank 18th in defensive EPA/play and have specifically struggled against the run, ranking 28th in defensive EPA/rush. That is good news for Bijan Robinson, who leads the league in scrimmage yards per game. Whether it is on the ground or in the passing game, Bijan Robinson is an unstoppable force. Michael Penix Jr. has struggled in his two road starts this season, but has been excellent at home. In his two home starts, he has four total touchdowns to one interception and is averaging 8.99 yards per attempt. The Falcons had a bye week to prepare for this game and should give a great effort, with a real chance to pull off the upset.

Seahawks +1.5 @ Jaguars — Sam Darnold has been playing at an incredible level this season. Seattle looks to have made the right decision, dumping Geno Smith and paying up for Darnold. Sam Darnold leads the league in EPA+CPOE composite and Jaxon Smith-Njigba ranks second in the NFL in receiving yards. This offense is explosive, and Jacksonville should struggle to slow them down. Travon Walker is likely to miss the game, which really hurts the Jaguars’ pass rush. Without that, they will need to cover on the outside, which is so tough against Smith-Njiba, Cooper Kupp, and the supporting cast. The Jaguars just had an emotional big win over the Chiefs on Monday night and could let down here on a short week.

Chargers -4.5 @ Dolphins — The Chargers need a big win. They looked great through the first several weeks of the season but have now lost back-to-back games. Their offense has been stifled by the Giants and Commanders the past two weeks. This is the perfect get-right spot against the Dolphins. Miami ranks 31st in defensive EPA/play and 32nd in defensive success rate. Justin Herbert should pick that secondary apart and get a big number on the board for Los Angeles. On the other side, the Chargers rank in the top eight in defensive EPA/play and defensive success rate. They should make life hard on Tua Tagovailoa and create negative plays. This has a real chance to turn into a blowout in the Chargers’ favor.

49ers +3.5 @ Buccaneers — The 49ers have looked great to start the season. Despite getting decimated by injuries, Kyle Shanahan has proven why he is one of the best coaches in the NFL. With Brock Purdy, George Kittle, Ricky Pearsall and Brandon Aiyuk all sidelined, Shanahan has Mac Jones running this offense at a high level. They should keep moving the ball efficiently against a Tampa Bay defense that ranks 20th in EPA/play and 22nd in success rate. On the other side, Baker Mayfield has been brilliant late in games to get wins. However, they have needed last-second scores to beat the Falcons, Jets, Texans and Seahawks. Tampa Bay has yet to win a game by more than three points this season, and this one should be tight as well, allowing San Francisco to cover the 3.5-point spread.

Chiefs -1.5 vs. Lions — The Chiefs and Lions face off in one of the biggest games of the weekend. Ever since getting handled in the opener against Green Bay, Detroit has been on a roll. However, those wins have come against the Browns, Ravens, Bengals and Bears. Those teams have a combined record of 6-13 this season. The Bears, Ravens and Bengals all rank in the bottom five of the NFL in defensive success rate. Meanwhile, the Browns, Bears and Bengals all rank in the bottom five of the NFL in offensive success rate. The Lions lost to the only good team they have faced this season and still need to prove they can beat a good team. The Chiefs are in a nearly must-win situation against Detroit at home, a spot where it’s hard not to back Patrick Mahomes. The Chiefs rank sixth in the NFL in offensive EPA/play and should score enough to get this big win.

Week 6 Leans

Giants +7.5 vs. Eagles

Bears +4.5 at Commanders

Colts -6.5 vs. Cardinals

Ravens +7.5 vs. Rams

Steelers -4.5 vs. Browns

Panthers +3.5 vs. Cowboys

Saints +3.5 vs. Patriots

Raiders -4.5 vs. Titans

Bengals +14.5 at Packers

Blake Krass has contributed to DraftKings since 2024, and is a content creator with a specialty in sports betting. Blake primarily focuses on college football and NFL coverage but will also be covering college basketball, the NBA, MLB and more. Prior to arriving at DK, Blake was a sports betting writer for The Action Network.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and customer (my username is blakekrass) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.