Week 4 of the 2025-26 NFL season continues with a great Sunday slate. There are far more ways to get involved in the action than just via traditional betting. One of the more unique features on DraftKings this season is Pick6 Fantasy Football!
Here are my top Pick6 plays for the Week 4 Sunday slate.
Cam Skattebo More Than 0.5 Rushing + Receiving TDs
Cam Skattebo is set for a big role in the Giants’ offense this week. After being relegated to a backup role to start the season, Skattebo will take over starting duties following the injury to Tyrone Tracy Jr. Skattebo came into the game last week against the Chiefs and ran the ball well. He finished with 60 yards and a touchdown on 10 carries. Giants rookie quarterback Jaxson Dart will be making his first career start in this game. Coach Brian Daboll will want to make things easy for his rookie quarterback and should lean on the run game, even utilizing Dart in read-option situations. Skattebo should have a great chance to find the end zone for the second straight game.

Deebo Samuel Sr. More Than 0.5 Rushing + Receiving TDs
The Commanders are riddled with injuries heading into this game against the Falcons. Jayden Daniels is set to miss his second straight game, and star receiver Terry McLaurin is also going to be sidelined. Noah Brown is out as well, while Jacory Croskey-Merritt is questionable. With all of these injuries, coach Kliff Kingsbury will need to lean on his veteran playmaker Deebo Samuel. Samuel is capable of making plays in the passing or running game. Samuel already has two touchdowns this season, one coming on the ground and one through the air. Washington will need to get creative on offense, and there is no better weapon than Samuel to be that multi-tool player.

Travis Etienne Jr. More Than 53.5 Rushing Yards
Travis Etienne went into this season expected to split carries with Tank Bigsby. However, Bigsby got traded to the Eagles at the start of the season. That is partially because of Jacksonville’s belief in rookie running back Bhayshul Tuten. However, it also means a bigger share of the carries for Travis Etienne. Last season, he was almost evenly splitting touches with Bigsby. While the Jaguars like what they see in Tuten, he is not getting as many touches as Bigsby did last year. That bigger share of carries has seen Etienne average 90 rushing yards per game this season. He has cleared 53.5 rushing yards in each game this season and should do so again in this game against the 49ers. For the 49ers, Nick Bosa is out for the season, and defensive tackle CJ West is out for this game. They will be thin on the defensive line, and that should allow Etienne to find running room. In a road game against a tough opponent, Jacksonville will want to run the ball to control the clock and keep the ball away from Brock Purdy. Etienne should clear this number for the fourth straight game to start the season.

What is DraftKings Pick6?
Pick6 is a peer-to-peer fantasy variant where you build a lineup (your “Pick Set”) of 2+ players and select whether you believe each will outperform their listed stat projection. Enter your Pick Set in Pick6 contests to compete against other users. Get enough picks correct and win a share of cash prizes.
How to Play
Create a Pick Set
Create a Pick Set by choosing 2+ players from the same sport and Pick Group (a set of picks available from a group of set competitions). For each player, simply select if you think they’ll have more or less than their listed stat projection. In each Pick Set, you can not pick the same player twice, and you must pick players from at least two different teams.
Enter an Amount
Once you finalize your Pick Set, choose your entry fee amount. Your entries will be automatically distributed into available contests, subject to your confirmation.
Sweat Your Picks
When the games go live, use the My Picks tab to follow your picks in real time to track how your players are performing against their projections and how they stack up against other users.
Compete for Prizes
Make enough correct picks and win a share of the contests’ guaranteed prizes. Any prizes won will be credited to your DraftKings account after contests are finalized.
Play at DraftKings Pick6 or by downloading the DraftKings Pick6 app on Apple or Google!