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Los Angeles Dodgers vs. Philadelphia Phillies prediction, pick for Wednesday 9/17/25

Los Angeles Dodgers vs. Philadelphia Phillies prediction, pick for Wednesday 9/17/25

Published:

By: Dan Johnson

Dodgers and Phillies collide in Los Angeles with both clubs locked into postseason positioning but chasing different goals. Philadelphia just clinched the NL East but is still vying for better seeding, while Los Angeles leads the NL West with one eye on maintaining leverage and shoring up home field advantages. The Phillies are limping into this last series missing key pieces—Trea Turner is out with a right hamstring strain, Alec Bohm is on the 10-day injured list with left shoulder inflammation. The Dodgers, meanwhile, are minus Will Smith due to a hand injury, who’d normally anchor right-hand power behind Ohtani and Betts. Below, I’ve got my preview, prediction, and best bet for this Wednesday baseball game between the Dodgers and the Phillies.

Here’s how I’ll play it. I’ll be pumping out these predictions for individual games all season, with plenty of coverage here on DraftKings Network. Follow my handle @dansby_edits for more betting plays.

Dodgers vs. Phillies prediction, preview

Blake Snell has looked every bit the ace since returning to the Dodgers’ rotation: 4–4, 2.79 ERA, 55 strikeouts in 48.1 innings, and only three balls left the yard across nine starts. He’s fresh off six scoreless with 11 punchouts against Colorado, the slider landing late and the four-seamer riding over barrels. That traffic you saw in his first couple turns has stabilized into a 1.39 WHIP with hitters batting .247 off him; once he’s ahead, it’s chase or roll over. On the other side, Jesús Luzardo brings a very different silhouette: volume and carry. He’s up to 200 strikeouts in 169.2 innings with a 14–6 record, a reminder that the Phillies acquired him to soak innings and tilt counts; five days ago he retired 22 straight Mets in an eight-inning, 10-K win after a rocky first frame. The headline reads “two lefties,” but the subhead is more important: two lefties currently in rhythm.

The recent context nudges this total down, not up. Philadelphia has taken 15 of 19 behind run prevention and one clean inning after another from a bullpen that now finishes with Jhoan Durán (31 saves, 1.88 ERA), the deadline hammer they paid to get. That matters because it shortens the path from Luzardo to the handshake line; he’s been working into the seventh and beyond with pitch efficiency, and Durán has been automatic in save situations since the trade. Los Angeles, meanwhile, has dropped the first two in this series despite a five-inning no-hit start and the 50th homer of the season from Shohei Ohtani on Tuesday—an absurd note that still ended 9–6 after a bullpen spiral. The lesson isn’t bet offense. It’s: trust the Phillies to lock the last six outs if the game is where they want it—and tonight’s matchup makes that likely.

Ohtani is sitting on 50 homers as we speak, a back-to-back 50-HR seasons milestone that bends game plans before first pitch; Freddie Freeman has lived at .290+ with an .850+ OPS; and Mookie Betts has heated up, going 18-for-43 with four homers and 17 RBI over his last 10. But the Dodgers are also without All-Star catcher Will Smith (10-day IL, bone bruise), which trims some lift-and-leverage behind those names and matters in run-scoring micro edges—receiving, swing decisions, and one extra premium at-bat a night. Across the field, Kyle Schwarber (53 HR, 128 RBI) and Bryce Harper (.265/.363/.500, 27 HR) are carrying the offense while Trea Turner (hamstring) and Alec Bohm (shoulder) work back from the IL, reshaping the Phillies’ run creation into thunder that arrives in clumps rather than a steady hum. When you bake all of that into a lefty-lefty night with premium strikeout arms, the base case is fewer long rallies, more solo risks you can survive.

Phillies vs. Dodgers pick, best bet

Dodger Stadium is one of those nuanced environments: it trims overall run scoring while still allowing the right kind of fly balls to leave. Statistically, you see it as a below-average run factor with an above-average home-run factor—fewer baserunners, but punishable mistakes. That’s precisely the profile you want with Snell and Luzardo: high-end strikeout stuff that limits traffic, with the occasional solo shot tolerated at an 8.0 number. Layer in a mild, dry Los Angeles night that rarely spikes carry the way the day games can, and the run environment is closer to neutral-lean-under than the market’s mid-8s lean would suggest.

Snell’s pitch mix (four-seam/slider/change) plays off elevated fastballs to left-handed thump, and while Schwarber and Harper punish mistakes, Snell has kept balls in the air from turning into two- and three-run shots by denying free passes once he’s settled. Across nine starts this season he’s run a 10.2 K/9 with opponents hitting .247, and he’s yielded just 3 HR in 48.1 IP—translating to a sub-0.60 HR/9 and keeping traffic thin with a 1.39 WHIP. His last outing (6.0 IP, 11 K, 0 R) showed the template: early strike efficiency into chase, then soft air contact when behind in the count. Luzardo’s four-seam/slider/change works in the other direction—he’ll live arm-side to right-handers and trusts the slider back foot to lefties—so the burden on the Dodgers’ right-hand bats to string singles is real without Smith’s on-base engine.

On the season he’s punched out 200 in 169.2 IP (≈10.6 K/9) and has traveled well, with a stronger run-prevention line on the road; right-handed hitters have been held in check (opponent average hovering in the low-.220s with sub-.730 OPS in that split), which is precisely where L.A. would normally lean on Smith to extend innings. If the script holds, you get six strong from each, a thinner middle-inning window, and a Phillies back end now anchored by Jhoan Duran waiting to slam the door if Philadelphia edges ahead. The only over risk is a Dodgers middle-relief stumble, but this is exactly the kind of spot where Snell’s swing-and-miss (double-digit K rate with only three homers allowed all year) buys Dave Roberts a shorter bridge

If you want to split exposure, the first-five under is an entirely reasonable corollary with these two lefties. But the full-game Under leans on three pillars—Snell’s present form, Luzardo’s workload/strikeouts, and a Phillies bullpen now headlined by Duran—that line up cleanly with the venue and the current rosters.

Best bet: Dodgers vs. Phillies u7.5 total runs (+100)

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Dan Johnson has been an editor, writer, and analyst for DraftKings and DraftKings Network since 2024. He’s previously held editorial posts at The Paris Review, Macmillan Publishers, Bedford/St. Martin’s Press, ASSIGNMENT Magazine, and FantasySixPack. You can find his various editorial work & writing (sports-related and non-) at all of the above.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user (my username is thegreatdansby9) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.