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DraftKings Pick6 Picks: Top Plays for Sunday NFL Week 2

DraftKings Pick6 Picks: Top Plays for Sunday NFL Week 2

Published:

By: Blake Krass

Week 2 of the 2025-26 NFL season continues with a great Sunday slate. There are far more ways to get involved in the action than just via traditional betting. One of the more unique features on DraftKings this season is Pick6 Fantasy Football!

Here are my top Pick6 plays for the Week 2 Sunday slate.

Christian McCaffrey More Than 0.5 Rushing + Receiving TDs

Christian McCaffrey is hoping to get back among the best running backs in the NFL this season. He led the league in rushing yards during the 2023-24 season, but then missed most of last year due to injuries. McCaffrey just handled 22 carries in the 49ers’ opener against the Seahawks, indicating that he is at full health to start the season. After a calf injury popped up a couple of days before that contest, there was a possibility that McCaffrey could be on a snap count or even miss the Week 1 game. However, McCaffrey seeing that many touches shows that he is ready to carry the load for the 49ers after all.

They will need him over the next few weeks as Brock Purdy is going to miss time for San Francisco. With backup quarterback Mac Jones leading the offense, they should lean heavily on McCaffrey, which should get him into the end zone.


CeeDee Lamb More Than 78.5 Receiving Yards

CeeDee Lamb is proving every season that he is one of the NFL’s best receivers. Since the start of the 2023 campaign, nobody has more receiving yards than Lamb. That is even more impressive given the fact that Dak Prescott missed much of the 2024-25 season due to injury. Even when Cooper Rush was in at quarterback, Lamb was putting up massive numbers. That being said, Lamb looked happy to have Dak Prescott back under center in Week 1. Even against the Eagles, one of the league’s best defenses, Lamb was able to put up big numbers. Lamb had seven catches for 110 yards in that game and still looked unstoppable despite a couple of bad drops to end the contest.

He should dominate the Giants’ secondary, which looked bad in Week 1 and ranked 23rd in defensive EPA/play. Lamb had 98 receiving yards and a score in the Cowboys’ matchup against the Giants that Prescott played in last season, and he should have a similar performance in this game.


Breece Hall More Than 60.5 Rushing Yards

Breece Hall posted a great Week 1 performance against the Steelers, a much-needed big game for Hall after a disappointing 2024-25 season. The halfback totaled 19 carries for 107 yards. Last season, the Jets ranked 29th in the NFL in rushing play percentage. Aaron Rodgers wanted the ball in his own hands as much as possible, so adding in the fact that Braelon Allen was getting a share of the carries as well, Hall just didn’t get much opportunity.

Now, this revamped offense with Justin Fields at quarterback should be much more beneficial for Hall. Fields is a great athlete who loves to run the football, so the threat of Fields’ legs will create more running lanes for the backfield. After Week 1, the Jets have the highest rushing play percentage in football, running on 62.9% of their plays against the Steelers. Derrick Henry just gashed the Bills for 169 yards last week, and while Hall might not reach that number, he should clear 60.5 rushing yards.


What is DraftKings Pick6?

Pick6 is a peer-to-peer fantasy variant where you build a lineup (your “Pick Set”) of 2+ players and select whether you believe each will outperform their listed stat projection. Enter your Pick Set in Pick6 contests to compete against other users. Get enough picks correct and win a share of cash prizes.

How to Play

Create a Pick Set

Create a Pick Set by choosing 2+ players from the same sport and Pick Group (a set of picks available from a group of set competitions). For each player, simply select if you think they’ll have more or less than their listed stat projection. In each Pick Set, you can not pick the same player twice, and you must pick players from at least two different teams.

Enter an Amount

Once you finalize your Pick Set, choose your entry fee amount. Your entries will be automatically distributed into available contests, subject to your confirmation.

Sweat Your Picks

When the games go live, use the My Picks tab to follow your picks in real time to track how your players are performing against their projections and how they stack up against other users.

Compete for Prizes

Make enough correct picks and win a share of the contests’ guaranteed prizes. Any prizes won will be credited to your DraftKings account after contests are finalized.


Play at DraftKings Pick6 or by downloading the DraftKings Pick6 app on Apple or Google!

Blake Krass has contributed to DraftKings since 2024, and is a content creator with a specialty in sports betting. Blake primarily focuses on college football and NFL coverage but will also be covering college basketball, the NBA, MLB and more. Prior to arriving at DK, Blake was a sports betting writer for The Action Network.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and customer (my username is blakekrass) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.